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首页> 外文期刊>Acta biomaterialia >Bone formation in TiO 2 bone scaffolds in extraction sockets of minipigs
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Bone formation in TiO 2 bone scaffolds in extraction sockets of minipigs

机译：小型猪拔牙窝中TiO 2骨支架的骨形成

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摘要

The osteoconductive capacity of TiO 2 scaffolds was investigated by analysing the bone ingrowth into the scaffold structure following their placement into surgically modified extraction sockets in Gottingen minipigs. Non-critical size defects were used in order to ensure sufficient bone regeneration for the evaluation of bone ingrowth to the porous scaffold structure, and sham sites were used as positive control. Microcomputed tomographic analysis revealed 73.6 ± 11.1% of the available scaffold pore space to be occupied by newly formed bone tissue, and the volumetric bone mineral density of the regenerated bone was comparable to that of the native cortical bone. Furthermore, histological evidence of vascularization and the presence of bone lamellae surrounding some of the blood vessels were also observed within the inner regions of the scaffold, indicating that the highly interconnected pore structure of the TiO 2 scaffolds supports unobstructed formation of viable bone tissue within the entire scaffold structure. In addition, bone tissue was found to be in direct contact with 50.0 ± 21.5% of the TiO 2 struts, demonstrating the good biocompatibility and osteoconductivity of the scaffold material.
机译：TiO 2支架的骨传导能力是通过分析将骨骼放置到Gottingen小型猪的手术改良拔牙窝中后向支架结构内的骨向内生长来研究的。为了确保足够的骨再生以评估骨向多孔支架结构的向内生长，使用了非临界大小的缺损，并且将假位点用作阳性对照。显微计算机断层扫描分析显示，可利用的支架孔空间中有73.6±11.1％被新形成的骨组织占据，并且再生骨的体积骨矿物质密度与天然皮质骨相当。此外，在支架的内部区域还观察到血管化的组织学证据和围绕某些血管的骨薄片的存在，这表明TiO 2支架的高度互连的孔结构支持在支架内无阻碍地形成活骨组织。整个脚手架结构。另外，发现骨组织与50.0±21.5％的TiO 2撑杆直接接触，证明了支架材料的良好的生物相容性和骨传导性。

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