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首页> 外文期刊>Acta biomaterialia >Mg-Zr-Sr alloys as biodegradable implant materials
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Mg-Zr-Sr alloys as biodegradable implant materials

机译：Mg-Zr-Sr合金作为可生物降解的植入物材料

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Novel Mg-Zr-Sr alloys have recently been developed for use as biodegradable implant materials. The Mg-Zr-Sr alloys were prepared by diluting Mg-Zr and Mg-Sr master alloys with pure Mg. The impact of Zr and Sr on the mechanical and biological properties has been thoroughly examined. The microstructures and mechanical properties of the alloys were characterized using optical microscopy, X-ray diffraction and compressive tests. The corrosion resistance was evaluated by electrochemical analysis and hydrogen evolution measurement. The in vitro biocompatibility was assessed using osteoblast-like SaOS2 cells and MTS and haemolysis tests. In vivo bone formation and biodegradability were studied in a rabbit model. The results indicated that both Zr and Sr are excellent candidates for Mg alloying elements in manufacturing biodegradable Mg alloy implants. Zr addition refined the grain size, improved the ductility, smoothed the grain boundaries and enhanced the corrosion resistance of Mg alloys. Sr addition led to an increase in compressive strength, better in vitro biocompatibility, and significantly higher bone formation in vivo. This study demonstrated that Mg-xZr-ySr alloys with x and y ≤5 wt.% would make excellent biodegradable implant materials for load-bearing applications.
机译：最近已经开发出新型的Mg-Zr-Sr合金用作可生物降解的植入物材料。通过用纯Mg稀释Mg-Zr和Mg-Sr中间合金来制备Mg-Zr-Sr合金。 Zr和Sr对机械和生物学性能的影响已得到彻底检验。使用光学显微镜，X射线衍射和压缩测试对合金的显微组织和力学性能进行了表征。通过电化学分析和析氢测量来评价耐腐蚀性。使用成骨细胞样SaOS2细胞，MTS和溶血试验评估了体外生物相容性。在兔子模型中研究了体内骨形成和生物降解性。结果表明，Zr和Sr都是制造可生物降解的Mg合金植入物时Mg合金元素的极佳候选者。 Zr的添加可以细化晶粒尺寸，改善延展性，平滑晶界并增强Mg合金的耐蚀性。 Sr的添加导致抗压强度的增加，更好的体外生物相容性和体内明显更高的骨形成。这项研究表明，x和y≤5 wt。％的Mg-xZr-ySr合金将成为出色的可生物降解植入材料，用于承重应用。

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