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首页> 外文期刊>Acta biomaterialia >Magnetic targeting of surface-modified superparamagnetic iron oxide nanoparticles yields antibacterial efficacy against biofilms of gentamicin-resistant staphylococci
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Magnetic targeting of surface-modified superparamagnetic iron oxide nanoparticles yields antibacterial efficacy against biofilms of gentamicin-resistant staphylococci

机译：表面改性的超顺磁性氧化铁纳米粒子的磁性靶向产生对庆大霉素抗性葡萄球菌生物膜的抗菌作用。

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摘要

Biofilms on biomaterial implants are hard to eradicate with antibiotics due to the protection offered by the biofilm mode of growth, especially when caused by antibiotic-resistant strains. Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used in various biomedical applications, such as targeted drug delivery and magnetic resonance imaging. Here, we evaluate the hypothesis that SPIONs can be effective in the treatment of biomaterial-associated infection. SPIONs can be targeted to the infection site using an external magnetic field, causing deep penetration in a biofilm and possibly effectiveness against antibiotic-resistant strains. We report that carboxyl-grafted SPIONs, magnetically concentrated in a biofilm, cause an approximately 8-fold higher percentage of dead staphylococci than does gentamicin for a gentamicin-resistant strain in a developing biofilm. Moreover, magnetically concentrated carboxyl-grafted SPIONs cause bacterial killing in an established biofilm. Thus magnetic targeting of SPIONs constitutes a promising alternative for the treatment of costly and recalcitrant biomaterial-associated infections by antibiotic-resistant strains.
机译：由于生物膜生长方式提供的保护，尤其是由抗药性菌株引起的生物膜植入物上的生物膜很难用抗生素根除。超顺磁性氧化铁纳米粒子（SPIONs）广泛用于各种生物医学应用中，例如靶向药物递送和磁共振成像。在这里，我们评估SPIONs可以有效治疗生物材料相关感染的假设。可以使用外部磁场将SPIONs靶向感染部位，从而引起生物膜的深层渗透，并可能有效抵抗抗生素耐药菌株。我们报告说，在生物膜中磁性浓缩的羧基接枝SPIONs引起的死葡萄球菌百分率比庆大霉素高，对正在发展的生物膜中的庆大霉素抗性菌株而言。此外，磁性浓缩的羧基接枝的SPIONs会在已建立的生物膜中杀死细菌。因此，SPIONs的磁性靶向构成了一种治疗抗生素耐药菌株的昂贵且难治的生物材料相关感染的有前途的替代方法。

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