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首页> 外文期刊>Acta biomaterialia >Polyethylene glycol-containing polyurethane hydrogel coatings for improving the biocompatibility of neural electrodes
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Polyethylene glycol-containing polyurethane hydrogel coatings for improving the biocompatibility of neural electrodes

机译：含聚乙二醇的聚氨酯水凝胶涂料，用于改善神经电极的生物相容性

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摘要

The instability of the interface between chronically implanted neuroprosthetic devices and neural tissue is a major obstacle to the long-term use of such devices in clinical practice. In this study, we investigate the feasibility of polyethylene glycol (PEG)-containing polyurethane (PU) hydrogel as coatings for polydimethylsiloxane (PDMS)-based neural electrodes in order to achieve a stable neural interface. The influence of PU hydrogel coatings on electrode electrochemical behaviour was investigated. Importantly, the biocompatibility of PU hydrogel coatings was evaluated in vitro and in vivo. Changes in the electrochemical impedance of microelectrodes with PU coatings were negligible. The amount of protein adsorption on the PDMS substrate was reduced by 93% after coating. Rat pheochromocytoma (PC12) cells exhibited more and longer neurites on PU films than on PDMS substrates. Furthermore, PDMS implants with (n = 10) and without (n = 8) PU coatings were implanted into the cortex of rats and the tissue response to the implants was evaluated 6 weeks post-implantation. GFAP staining for astrocytes and NeuN staining for neurons revealed that PU coatings attenuated glial scarring and reduced the neuronal cell loss around the implants. All of these findings suggest that PU hydrogel coating is feasible and favourable for neural electrode applications.
机译：长期植入的神经假体设备和神经组织之间的界面不稳定是在临床实践中长期使用此类设备的主要障碍。在这项研究中，我们调查了含聚乙二醇（PEG）的聚氨酯（PU）水凝胶作为基于聚二甲基硅氧烷（PDMS）的神经电极涂层的可行性，以实现稳定的神经界面。研究了聚氨酯水凝胶涂层对电极电化学行为的影响。重要的是，在体外和体内评估了PU水凝胶涂层的生物相容性。带有PU涂层的微电极的电化学阻抗变化可忽略不计。包被后，蛋白质在PDMS基材上的吸附量减少了93％。大鼠嗜铬细胞瘤（PC12）细胞在PU膜上比在PDMS基质上表现出更多和更长的神经突。此外，将具有（n = 10）和不具有（n = 8）PU涂层的PDMS植入物植入大鼠皮质，并在植入后6周评估对植入物的组织反应。星形胶质细胞的GFAP染色和神经元的NeuN染色显示，PU涂层可减轻胶质瘢痕形成并减少植入物周围的神经元细胞损失。所有这些发现表明，PU水凝胶涂层是可行的并且对于神经电极应用是有利的。

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