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首页> 外文期刊>Acta biomaterialia >Biocompatibility and biodegradability of Mg-Sr alloys: The formation of Sr-substituted hydroxyapatite
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Biocompatibility and biodegradability of Mg-Sr alloys: The formation of Sr-substituted hydroxyapatite

机译：Mg-Sr合金的生物相容性和生物降解性：Sr取代羟基磷灰石的形成

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摘要

Magnesium is an attractive material for use in biodegradable implants due to its low density, non-toxicity and mechanical properties similar to those of human tissue such as bone. Its biocompatibility makes it amenable for use in a wide range of applications from bone to cardiovascular implants. Here we investigated the corrosion rate in simulated body fluid (SBF) of a series of Mg-Sr alloys, with Sr in the range of 0.3-2.5%, and found that the Mg-0.5 Sr alloy showed the slowest corrosion rate. The degradation rate from this alloy indicated that the daily Sr intake from a typical stent would be 0.01-0.02 mg day-1, which is well below the maximum daily Sr intake levels of 4 mg day-1. Indirect cytotoxicity assays using human umbilical vascular endothelial cells indicated that Mg-0.5 Sr extraction medium did not cause any toxicity or detrimental effect on the viability of the cells. Finally, a tubular Mg-0.5 Sr stent sample, along with a WE43 control stent, was implanted into the right and left dog femoral artery. No thrombosis effect was observed in the Mg-0.5 Sr stent after 3 weeks of implantation while the WE43 stent thrombosed. X-ray diffraction demonstrated the formation of hydroxyapatite and Mg(OH) 2 as a result of the degradation of Mg-0.5 Sr alloy after 3 days in SBF. X-ray photoelectron spectroscopy further showed the possibility of the formation of a hydroxyapatite Sr-substituted layer that presents as a thin layer at the interface between the Mg-0.5 Sr alloy and the corrosion products. We believe that this interfacial layer stabilizes the surface of the Mg-0.5 Sr alloy, and slows down its degradation rate over time. ? 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
机译：镁是一种可生物降解植入物的诱人材料，因为它的密度低，无毒且机械性能类似于人体组织（如骨骼）。它的生物相容性使其适合于从骨骼到心血管植入物的广泛应用。在这里，我们研究了一系列Sr在0.3-2.5％范围内的Mg-Sr合金在模拟体液（SBF）中的腐蚀速率，发现Mg-0.5 Sr合金的腐蚀速率最慢。该合金的降解速率表明，典型支架的每日Sr摄入量为0.01-0.02 mg第1天，远低于第1天4 mg的最大每日Sr摄入水平。使用人脐带血管内皮细胞的间接细胞毒性试验表明，Mg-0.5 Sr提取培养基不会对细胞活力产生任何毒性或有害影响。最后，将管状Mg-0.5 Sr支架样品以及WE43对照支架植入到左右犬股动脉中。植入3周后，在Mg-0.5 Sr支架中未观察到血栓形成作用，而WE43支架发生了血栓形成。 X射线衍射表明，在SBF中放置3天后，由于Mg-0.5 Sr合金的降解，形成了羟基磷灰石和Mg（OH）2。 X射线光电子能谱进一步显示了形成羟基磷灰石Sr取代层的可能性，该羟基磷灰石Sr取代层在Mg-0.5 Sr合金与腐蚀产物之间的界面处呈现为薄层。我们相信，该界面层可稳定Mg-0.5 Sr合金的表面，并减缓其随时间的降解速度。 ？ 2012年Acta Materialia Inc.由Elsevier Ltd.发行。保留所有权利。

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