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首页> 外文期刊>Acta biomaterialia >Direct synthesis of heparin-like poly(ether sulfone) polymer and its blood compatibility
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Direct synthesis of heparin-like poly(ether sulfone) polymer and its blood compatibility

机译：肝素样聚醚砜聚合物的直接合成及其血液相容性

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In this study, heparin-like poly(ethersulfone) (HLPES) was synthesized by a combination of polycondensation and post-carboxylation methods, and was characterized by Fourier transform infrared spectroscopy, nuclear magnetic resonance hydrogen spectrum and gel permeation chromatography. Owing to the similar backbone structure, the synthesized HLPES could be directly blended with pristine PES at any ratios to prepare PES/HLPES membranes. After the introduction of HLPES, the microscopic structure of the modified PES membranes was changed, while the hydrophilicity was significantly enhanced. Bovine serum albumin and bovine serum fibrinogen adsorption, activated partial thromboplastin time, thromb time and platelet adhesion for the modified PES membranes were investigated. The results indicated that the blood compatibility of the PES/HLPES membranes was significantly improved compared with that of pristine PES membrane. For the PES/HLPES membranes, obvious decreases in platelet activation on PF-4 level, in complement activation on C3a and C5a levels, and in leukocytes activation on CD11b levels were observed compared with those for the pristine PES membrane. The improved blood compatibility of the PES/HLPES membrane might due to the existence of the hydrophilic groups (-SO 3Na, -COONa). Furthermore, the modified PES membranes showed good cytocompatibility. Hepatocytes cultured on the PES/HLPES membranes presented improved growth in terms of SEM observation, MTT assay and confocal laser scanning microscope observation compared with those on the pristine PES membrane. These results indicate that the PES/HLPES membranes present great potential in blood-contact fields such as hemodialysis and bio-artificial liver supports.
机译：在这项研究中，肝素样聚醚砜（HLPES）是通过缩聚和后羧化方法相结合合成的，并通过傅里叶变换红外光谱，核磁共振氢谱和凝胶渗透色谱法进行了表征。由于类似的骨架结构，可以将合成的HLPES以任何比例直接与原始PES共混以制备PES / HLPES膜。引入HLPES后，改性的PES膜的微观结构发生了变化，而亲水性得到了显着增强。研究了改性PES膜的牛血清白蛋白和牛血清纤维蛋白原的吸附，活化的部分凝血活酶时间，血栓时间和血小板粘附性。结果表明，与原始PES膜相比，PES / HLPES膜的血液相容性显着提高。对于PES / HLPES膜，与原始PES膜相比，在PF-4水平上的血小板活化，在C3a和C5a水平上的补体活化以及在CD11b水平上的白细胞活化均明显降低。 PES / HLPES膜改善的血液相容性可能归因于亲水基团（-SO 3Na，-COONa）的存在。此外，改性的PES膜显示出良好的细胞相容性。与原始PES膜相比，在PES / HLPES膜上培养的肝细胞在SEM观察，MTT分析和共聚焦激光扫描显微镜观察方面表现出改善的生长。这些结果表明，PES / HLPES膜在血液接触领域（如血液透析和生物人工肝支持）具有巨大潜力。

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