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首页> 外文期刊>Acta biomaterialia >Predictive biomechanical analysis of ascending aortic aneurysm rupture potential
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Predictive biomechanical analysis of ascending aortic aneurysm rupture potential

机译：升主动脉瘤破裂潜能的预测生物力学分析

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Aortic aneurysm is a leading cause of death in adults, often taking lives without any premonitory signs or symptoms. Adverse clinical outcomes of aortic aneurysm are preventable by elective surgical repair; however, identifying at-risk individuals is difficult. The objective of this study was to perform a predictive biomechanical analysis of ascending aortic aneurysm (AsAA) tissue to assess rupture risk on a patient-specific level. AsAA tissues, obtained intra-operatively from 50 patients, were subjected to biaxial mechanical and uniaxial failure tests to obtain their passive elastic mechanical properties. A novel analytical method was developed to predict the AsAA pressure-diameter response as well as the aortic wall yield and failure responses. Our results indicated that the mean predicted AsAA diameter at rupture was 5.6 ± 0.7 cm, and the associated blood pressure to induce rupture was 579.4 ± 214.8 mmHg. Statistical analysis showed significant positive correlation between aneurysm tissue compliance and predicted risk of rupture, where patients with a pressure-strain modulus ≥100 kPa may be nearly twice as likely to experience rupture than patients with more compliant aortic tissue. The mechanical analysis of pre-dissection patient tissue properties established in this study could predict the "future" onset of yielding and rupture in AsAA patients. The analysis results implicate decreased tissue compliance as a risk factor for AsAA rupture. The presented methods may serve as a basis for the development of a pre-operative planning tool for AsAA evaluation, a tool currently unavailable.
机译：主动脉瘤是成人死亡的主要原因，通常夺去生命而没有任何先兆或症状。主动脉瘤的不良临床结局可通过择期外科手术修复来预防;但是，很难确定有风险的个人。这项研究的目的是对升主动脉瘤（AsAA）组织进行预测性生物力学分析，以评估患者特定水平的破裂风险。术中从50例患者中获得的AsAA组织接受了双轴力学和单轴破坏测试，以获得其被动弹性力学性能。开发了一种新颖的分析方法来预测AsAA压力-直径响应以及主动脉壁屈服和衰竭响应。我们的结果表明，破裂时AsAA的平均预测直径为5.6±0.7 cm，诱发破裂的相关血压为579.4±214.8 mmHg。统计分析表明，动脉瘤组织顺应性与预测的破裂风险之间存在显着的正相关性，其中压力应变模量≥100kPa的患者发生破裂的可能性可能是主动脉组织较顺应性患者的近两倍。在这项研究中建立的解剖前患者组织特性的力学分析可以预测AsAA患者屈服和破裂的“未来”发作。分析结果暗示组织顺应性下降是AsAA破裂的危险因素。提出的方法可作为开发用于AsAA评估的术前计划工具的基础，该工具目前尚不可用。

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