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首页> 外文期刊>Acta biomaterialia >Dissolution patterns of biocompatible glasses in 2-Amino-2-hydroxymethyl- propane-1,3-diol (Tris) buffer
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Dissolution patterns of biocompatible glasses in 2-Amino-2-hydroxymethyl- propane-1,3-diol (Tris) buffer

机译：生物相容性玻璃在2-氨基-2-羟甲基丙烷-1,3-二醇（Tris）缓冲液中的溶解模式

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摘要

A continuous flow measurement system with sensitive on-line ion analysis has been applied to study the initial dissolution behaviour of biocompatible glasses in Tris. Altogether 16 glasses with widely varying compositions were studied. The measurement system allowed for quantitative determination of the time-dependent rates of dissolution of sodium, potassium, calcium, magnesium, silicon and phosphorus during the first 10-15 min in contact with Tris solution. The dissolution rates of the different ions showed significant glass to glass variations, but all glasses studied showed one of four distinct dissolution patterns. The ion dissolution rates after an exposure of 1000 s, expressed as the normalized surface-specific mass loss rates, were compared with the in vitro and in vivo reactivity of the glasses as predicted by models in the literature. The results showed a clear correlation between the dissolution rates of the glasses in Tris and their reactivity as measured by other different methods. Consequently, the measured short-term dissolution patterns could be used to determine which glasses are suitable as bioactive, biodegradable, or inert biomaterials for medical devices. ? 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
机译：具有灵敏在线离子分析的连续流量测量系统已用于研究Tris中生物相容性玻璃的初始溶解行为。共研究了16种具有广泛变化成分的玻璃。该测量系统可以定量确定与Tris溶液接触的前10-15分钟内钠，钾，钙，镁，硅和磷的时间依赖性溶出速率。不同离子的溶解速率显示出不同玻璃之间的显着差异，但研究的所有玻璃均显示出四种不同的溶解模式之一。如文献中的模型所预测的，将暴露于1000 s后的离子溶解率（表示为标准化的表面比质量损失率）与玻璃的体外和体内反应性进行了比较。结果表明，通过其他不同方法测得，玻璃在Tris中的溶解速率与其反应性之间存在明显的相关性。因此，测得的短期溶出度图可用于确定哪种玻璃适合用作医疗器械的生物活性，可生物降解或惰性生物材料。 ？ 2012年Acta Materialia Inc.由Elsevier Ltd.发行。保留所有权利。

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