• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >PH-dependent antibacterial effects on oral microorganisms through pure PLGA implants and composites with nanosized bioactive glass
【24h】

PH-dependent antibacterial effects on oral microorganisms through pure PLGA implants and composites with nanosized bioactive glass

机译：通过纯PLGA植入物和具有纳米生物活性玻璃的复合材料对口腔微生物产生PH依赖性抗菌作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Biomaterials made of biodegradable poly(α-hydroxyesters) such as poly(lactide-co-glycolide) (PLGA) are known to decrease the pH in the vicinity of the implants. Bioactive glass (BG) is being investigated as a counteracting agent buffering the acidic degradation products. However, in dentistry the question arises whether an antibacterial effect is rather obtained from pure PLGA or from BG/PLGA composites, as BG has been proved to be antimicrobial. In the present study the antimicrobial properties of electrospun PLGA and BG45S5/PLGA fibres were investigated using human oral bacteria (specified with mass spectrometry) incubated for up to 24 h. BG45S5 nanoparticles were prepared by flame spray synthesis. The change in colony-forming units (CFU) of the bacteria was correlated with the pH of the medium during incubation. The morphology and structure of the scaffolds as well as the appearance of the bacteria were followed bymicroscopy. Additionally, we studied if the presence of BG45S5 had an influence on the degradation speed of the polymer. Finally, it turned out that the pH increase induced by the presence of BG45S5 in the scaffold did not last long enough to show a reduction in CFU. On the contrary, pure PLGA demonstrated antibacterial properties that should be taken into consideration when designing biomaterials for dental applications.
机译：已知由可生物降解的聚（α-羟基酯）制成的生物材料，例如聚（丙交酯-共-乙交酯）（PLGA），会降低植入物附近的pH。正在研究生物活性玻璃（BG）作为缓冲酸性降解产物的抗衡剂。然而，在牙科领域中出现的问题是究竟是从纯PLGA还是从BG / PLGA复合材料获得抗菌效果，因为BG已被证明具有抗菌作用。在本研究中，使用孵育长达24小时的人类口腔细菌（用质谱法指定）研究了电纺PLGA和BG45S5 / PLGA纤维的抗菌特性。 BG45S5纳米粒子通过火焰喷涂合成制备。孵育过程中细菌菌落形成单位（CFU）的变化与培养基的pH相关。通过显微镜观察支架的形态和结构以及细菌的外观。另外，我们研究了BG45S5的存在是否对聚合物的降解速度有影响。最终，结果表明由支架中BG45S5的存在引起的pH升高持续的时间不足以显示CFU的降低。相反，在设计用于牙科应用的生物材料时，纯PLGA表现出抗菌特性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号