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首页> 外文期刊>Acta biomaterialia >Composite hydrogels as a vehicle for releasing drugs with a wide range of hydrophobicities
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Composite hydrogels as a vehicle for releasing drugs with a wide range of hydrophobicities

机译：复合水凝胶作为释放具有广泛疏水性的药物的载体

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摘要

Many vitamins, bioactive lipids and over 40% of newly developed drugs are hydrophobic, and their poor water solubility limits their delivery using conventional formulations. In this work we investigated a composite gel system formulated from microemulsions embedded in alginate hydrogels, and showed that it is capable of loading several hydrophobic compounds with a wide range of aqueous solubility. All gels were clear, with no precipitations, indicating the solubility of the drugs in the gels. The release behavior was similar for different microemulsion formulations, various drugs and increasing concentrations of a drug. These findings indicate that our system could potentially act as a generic system, where the properties of the release do not depend on the drug but rather on the attributes of the gel. The structure of composite gels was investigated using small-angle scattering of X-rays and neutrons (SAXS and SANS, respectively). SANS showed more sensitivity to the structure of the microemulsion in the composite gel than SAXS did. SAXS and SANS plots of the composite gels show that both the droplets and the gel network preserve their structure when mixed together.
机译：许多维生素，生物活性脂质和40％以上的新开发药物都是疏水性的，它们的水溶性差，限制了它们使用常规制剂的输送。在这项工作中，我们研究了由嵌入藻酸盐水凝胶中的微乳配制的复合凝胶体系，并表明它能够负载多种疏水性化合物，并具有广泛的水溶性。所有凝胶都是透明的，没有沉淀，表明药物在凝胶中的溶解度。对于不同的微乳液制剂，各种药物和增加的药物浓度，其释放行为是相似的。这些发现表明，我们的系统可能会充当通用系统，其中释放的特性不取决于药物，而是取决于凝胶的属性。使用X射线和中子的小角度散射（分别为SAXS和SANS）研究了复合凝胶的结构。与SAXS相比，SANS对复合凝胶中微乳液的结构显示出更高的敏感性。复合凝胶的SAXS和SANS图显示，液滴和凝胶网络在混合在一起时都可以保留其结构。

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