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首页> 外文期刊>Acta biomaterialia >Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material
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Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material

机译：评估原位化学交联水凝胶作为长期的玻璃替代材料

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摘要

Currently there is no material that can be used as a long-term vitreous substitute, and this remains an unmet clinical need in ophthalmology. In this study, we developed an injectable, in situ chemically crosslinked hydrogel system and evaluated it in a rabbit model. The system consisted of two components, both based on multi-functional poly(ethylene glycol) (PEG) but with complementarily reactive end groups of thiol and active vinyl groups, respectively. The two components are mixed and injected as a solution mixture, react in vivo via the Michael addition route and form a chemically crosslinked hydrogel in situ. The linkages between the end groups and the backbone PEG chains are specially designed to ensure that the final network structure is hydrolysis-resistant. In the rabbit study and with an optimized operation protocol, we demonstrated that the hydrogel indeed formed in situ after injection, and remained transparent and stable during the study period of 9 months without significant adverse reactions. In addition, the hydrogel formed in situ showed rheological properties very similar to the natural vitreous. Therefore, our study demonstrated that this in situ chemically crosslinked PEG gel system is suitable as a potential long-term vitreous substitute. Crown
机译：当前，没有可以用作玻璃体长期替代物的材料，这仍然是眼科领域尚未满足的临床需求。在这项研究中，我们开发了一种可注射的原位化学交联水凝胶系统，并在兔子模型中对其进行了评估。该系统由两个组分组成，这两个组分均基于多功能聚乙二醇（PEG），但分别具有互补的巯基和活性乙烯基反应性端基。将这两种组分混合并作为溶液混合物注入，通过迈克尔加成途径在体内反应并原位形成化学交联的水凝胶。端基和主链PEG链之间的连接经过特殊设计，以确保最终的网络结构具有抗水解性。在兔子的研究中，并通过优化的操作规程，我们证明了水凝胶确实在注射后就地形成，并且在9个月的研究期内保持透明和稳定，没有明显的不良反应。另外，原位形成的水凝胶显示出与天然玻璃非常相似的流变性质。因此，我们的研究表明，这种原位化学交联的PEG凝胶体系适合作为潜在的长期玻璃体替代物。王冠

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