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首页> 外文期刊>Acta biomaterialia >Investigation of the three-dimensional orientation of mineralized collagen fibrils in human lamellar bone using synchrotron X-ray phase nano-tomography
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Investigation of the three-dimensional orientation of mineralized collagen fibrils in human lamellar bone using synchrotron X-ray phase nano-tomography

机译：使用同步加速器X射线相纳米断层扫描技术研究层状骨中矿化胶原纤维的三维取向

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摘要

We investigate the three-dimensional (3-D) organization of mineralized collagen fibrils in human cortical bone based on synchrotron X-ray phase nano-tomography images. In lamellar bone the collagen fibrils are assumed to have a plywood-like arrangement, but due to experimental limitations the 3-D fibril structure has only been deduced from section surfaces so far and the findings have been controversial. Breakthroughs in synchrotron tomographic imaging have given access to direct 3-D information on the bone structure at the nanoscale level. Using an autocorrelation-based orientation measure we confirm that the fibrils are unidirectional in quasi-planes of sub-lamellae and find two specific dominant patterns, oscillating and twisted plywoods coexisting in a single osteon. Both patterns exhibit smooth orientation changes between adjacent quasi-planes. Moreover, we find that the periodic changes in collagen fibril orientation are independent of fluctuations in local mass density. These data improve our understanding of the lamellar arrangement in bone and allow more detailed investigations of structure-function relationships at this scale, providing templates for bio-inspired materials. The presented methodology can be applied to non-destructive 3-D characterization of the sub-micron scale structure of other natural and artificial mineralized biomaterials.
机译：我们基于同步加速器X射线相纳米断层扫描图像调查人类皮质骨中矿化的胶原纤维的三维（3-D）组织。在层状骨中，胶原蛋白原纤维被认为具有胶合板状的排列，但是由于实验的局限性，到目前为止，仅从截面表面推断出3-D原纤维的结构，这一发现存在争议。同步加速器层析成像的突破性进展使人们能够在纳米级获得有关骨骼结构的直接3-D信息。使用基于自相关的定向度量，我们确认了原纤维在亚层板的准平面中是单向的，并找到了两个特定的主导模式，即在单个骨中共存的振荡和扭曲胶合板。两种图案在相邻的准平面之间都显示出平滑的方向变化。此外，我们发现胶原蛋白原纤维取向的周期性变化与局部质量密度的波动无关。这些数据提高了我们对骨骼中层状排列的理解，并允许在此规模下更详细地研究结构-功能关系，从而为生物启发性材料提供了模板。所提出的方法可以应用于其他天然和人工矿化生物材料的亚微米尺度结构的无损3-D表征。

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