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首页> 外文期刊>Acta biomaterialia >Biological responses of silver-coated thermosets: An in vitro and in vivo study
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Biological responses of silver-coated thermosets: An in vitro and in vivo study

机译：涂银热固性塑料的生物学响应：一项体外和体内研究

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摘要

Bisphenol A glycidylmethacrylate (BisGMA)/triethyleneglycol dimethacrylate (TEGDMA) thermosets are biomaterials commonly employed for orthopedic and dental applications; for both these fields, bacterial adhesion to the surface of the implant represents a major issue for the outcome of the surgical procedures. In this study, the antimicrobial properties of a nanocomposite coating formed by polysaccharide 1-deoxylactit-1-yl chitosan (Chitlac) and silver nanoparticles (nAg) on methacrylate thermosets were studied. The Chitlac-nAg system showed good anti-bacterial and anti-biofilm activity although its biocidal properties can be moderately, albeit significantly, inhibited by serum proteins. In vitro studies on the silver release kinetic in physiological conditions showed a steady metal release associated with a gradual loss of antimicrobial activity. However, after 3 weeks there was still effective protection against bacterial colonization which could be accounted for by the residual silver. This time-span could be considered adequate to confer short-term protection from early peri-implant infections. Preliminary in vivo tests in a mini-pig animal model showed good biological compatibility of Chitlac-nAg-coated materials when implanted in bony tissue. The comparison was made with implants of titanium Ti6Al4V alloy and with a Chitlac-coated thermoset. Bone healing patterns and biocompatibility parameters observed for nAg-treated material were comparable with those observed for control implants. ? 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
机译：双酚A甲基丙烯酸缩水甘油酯（BisGMA）/三乙二醇二甲基丙烯酸酯（TEGDMA）热固性材料是骨科和牙科应用中常用的生物材料。对于这两个领域，细菌对植入物表面的粘附代表了外科手术结果的主要问题。在这项研究中，研究了由多糖1-脱氧乳酸-1-基壳聚糖（Chitlac）和银纳米颗粒（nAg）在甲基丙烯酸酯热固性材料上形成的纳米复合涂层的抗菌性能。 Chitlac-nAg系统显示出良好的抗菌和抗生物膜活性，尽管其杀生物特性可以被血清蛋白适度（尽管明显）抑制。在生理条件下对银释放动力学的体外研究表明，金属的稳定释放与抗菌活性的逐渐降低有关。但是，三周后，仍然可以有效抵抗细菌定植，这可以由残留的银来解释。该时间跨度可以认为足以为早期的种植体周围感染提供短期保护。小型猪动物模型中的初步体内测试显示，当将Chitlac-nAg涂层的材料植入骨组织时，具有良好的生物相容性。使用钛Ti6Al4V合金植入物和Chitlac涂层热固性树脂进行了比较。经nAg处理的材料观察到的骨愈合模式和生物相容性参数与对照植入物所观察到的相当。 ？ 2012年Acta Materialia Inc.由Elsevier Ltd.发行。保留所有权利。

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