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首页> 外文期刊>Acta biomaterialia >New biotextiles for tissue engineering: Development, characterization and in vitro cellular viability
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New biotextiles for tissue engineering: Development, characterization and in vitro cellular viability

机译：用于组织工程的新型生物纺织品：开发，表征和体外细胞生存力

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摘要

This work proposes biodegradable textile-based structures for tissue engineering applications. We describe the use of two polymers, polybutylene succinate (PBS) proposed as a viable multifilamentand silk fibroin (SF), to produce fibre-based finely tuned porous architectures by weft knitting. PBS is here proposed as a viable extruded multifilament fibre to be processed by a textile-based technology. A comparative study was undertaken using a SF fibre with a similar linear density. The knitted constructs obtained are described in terms of their morphology, mechanical properties, swelling capability, degradation behaviour and cytotoxicity. The weft knitting technology used offers superior control over the scaffold design (e.g. size, shape, porosity and fibre alignment), manufacturing and reproducibility. The presented fibres allow the processing of a very reproducible intra-architectural scaffold geometry which is fully interconnected, thus providing a high surface area for cell attachment and tissue in-growth. The two types of polymer fibre allow the generation of constructs with distinct characteristics in terms of the surface physico-chemistry, mechanical performance and degradation capability, which has an impact on the resulting cell behaviour at the surface of the respective biotextiles. Preliminary cytotoxicity screening showed that both materials can support cell adhesion and proliferation. These results constitute a first validation of the two biotextiles as viable matrices for tissue engineering prior to the development of more complex systems. Given the processing efficacy and versatility of the knitting technology and the interesting structural and surface properties of the proposed polymer fibres it is foreseen that the developed systems could be attractive for the functional engineering of tissues such as skin, ligament, bone or cartilage.
机译：这项工作提出了用于组织工程应用的基于生物可降解纺织品的结构。我们描述了使用两种聚合物，即作为可行的复丝的聚丁二酸丁二酯（PBS）和丝素蛋白（SF），通过纬编生产基于纤维的微调多孔结构。 PBS在这里被提出作为一种可行的挤出复丝纤维，将通过基于纺织品的技术进行处理。使用具有相似线密度的SF纤维进行了比较研究。根据其形态，机械性能，溶胀能力，降解行为和细胞毒性描述了所得的针织结构。所使用的纬编技术可提供对支架设计（例如尺寸，形状，孔隙率和纤维排列），制造和可复制性的出色控制。呈现的纤维允许完全互连的非常可再现的建筑内支架几何结构的加工，因此为细胞附着和组织向内生长提供了高表面积。两种类型的聚合物纤维允许产生在表面物理化学，机械性能和降解能力方面具有不同特征的构建体，这对相应生物织物表面上的所得细胞行为产生影响。初步的细胞毒性筛选显示，两种材料均可支持细胞粘附和增殖。这些结果构成了在开发更复杂的系统之前，两种生物纺织品作为可行的组织工程基质的首次验证。考虑到针织技术的加工效率和多功能性以及所提出的聚合物纤维的令人感兴趣的结构和表面特性，可以预见，开发的系统可能对诸如皮肤，韧带，骨骼或软骨等组织的功能工程具有吸引力。

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