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首页> 外文期刊>Acta biomaterialia >Development of high refractive ZnS/PVP/PDMAA hydrogel nanocomposites for artificial cornea implants
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Development of high refractive ZnS/PVP/PDMAA hydrogel nanocomposites for artificial cornea implants

机译：用于人工角膜植入物的高折射ZnS / PVP / PDMAA水凝胶纳米复合材料的开发

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摘要

A series of high refractive index (RI) ZnS/PVP/PDMAA hydrogel nanocomposites containing ZnS nanoparticles (NPs) were successfully synthesized via a simple ultraviolet-light-initiated free radical co-polymerization method. The average diameter of the ZnS NPs is ～3 nm and the NPs are well dispersed and stabilized in the PVP/PDMAA hydrogel matrix up to a high content of 60 wt.% in the hydrogel nanocomposites. The equilibrium water content of ZnS/PVP/PDMAA hydrogel nanocomposites varied from 82.0 to 66.8 wt.%, while the content of mercaptoethanol-capped ZnS NPs correspondingly varied from 30 to 60 wt.%. The resulting nanocomposites are clear and transparent and their RIs were measured to be as high as 1.58-1.70 and 1.38-1.46 in the dry and hydrated states, respectively, which can be tuned by varying the ZnS NPs content. In vitro cytotoxicity assays suggested that the introduction of ZnS NPs added little cytotoxicity to the PVP/PDMAA hydrogel and all the hydrogel nanocomposites exhibited minimal cytotoxicity towards common cells. The hydrogel nanocomposites implanted in rabbit eyes can be well tolerated over 3 weeks. Hence, the high RI ZnS/PVP/PDMAA hydrogel nanocomposites with adjustable RIs developed in this work might potentially be a candidate material for artificial corneal implants.
机译：通过简单的紫外光引发的自由基共聚合方法成功地合成了一系列含有ZnS纳米颗粒（NPs）的高折射率（RI）ZnS / PVP / PDMAA水凝胶纳米复合材料。 ZnS NPs的平均直径约为3 nm，并且NPs在PVP / PDMAA水凝胶基质中分散良好并稳定，在水凝胶纳米复合材料中含量高达60 wt。％。 ZnS / PVP / PDMAA水凝胶纳米复合材料的平衡水含量为82.0至66.8 wt。％，而巯基乙醇封端的ZnS NP的含量相应地为30至60 wt。％。所得的纳米复合材料是透明和透明的，在干燥和水合状态下，其RIs分别高达1.58-1.70和1.38-1.46，这可以通过改变ZnS NPs的含量来调节。体外细胞毒性试验表明，ZnS NPs的引入对PVP / PDMAA水凝胶几乎没有细胞毒性，所有水凝胶纳米复合材料对普通细胞的细胞毒性最小。植入兔眼的水凝胶纳米复合材料在3周内可以很好地耐受。因此，在这项工作中开发的具有可调节RI的高RI ZnS / PVP / PDMAA水凝胶纳米复合材料可能是人工角膜植入物的候选材料。

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