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首页> 外文期刊>Acta Dermato-Venereologica >Repeated open application tests (ROAT) in patients allergic to colophony--evaluated visually and with bioengineering techniques.
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Repeated open application tests (ROAT) in patients allergic to colophony--evaluated visually and with bioengineering techniques.

机译：对口香糖过敏的患者进行重复的开放式应用测试（ROAT），通过视觉和生物工程技术进行评估。

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摘要

It is desirable to further evaluate the clinical relevance of a positive patch test. The repeated open application test (ROAT) has been suggested as such a supplementary method. To compare the results of patch testing with the outcome of ROATs, 13 colophony-sensitive subjects and 9 controls were patch-tested with colophony in a serial dilution test. Five microliters, of three concentrations of a colophony solution and the vehicle were then applied to small test areas on the lower arm, once daily for 2 weeks. Prior to each application, all test sites were examined visually and with bioengineering techniques. In the ROATs, 10/13 colophony-sensitive subjects--but no controls--reacted to a 20% colophony solution, 4 also 1%. A correlation was found between the threshold concentration at patch testing and the outcome of ROATs. There was great variation in the reactivity in the ROATs. Objective measures for evaluating the ROAT reactions gave no further information than visual assessment.
机译：希望进一步评估阳性斑贴试验的临床相关性。有人建议重复开放应用测试（ROAT）作为这种补充方法。为了将斑贴测试的结果与ROAT的结果进行比较，在连续稀释度测试中，对13位对口香糖敏感的受试者和9位对照进行了口香糖的斑贴测试。然后将五微升，三种浓度的树脂溶液和媒介物应用于下臂的小测试区域，每天一次，持续2周。每次应用之前，都要目视和使用生物工程技术对所有测试地点进行检查。在ROAT中，对10/13对口香糖敏感的受试者（但没有对照组）对20％的口香糖溶液进行了反应，其中4位也对1％进行了反应。在斑贴测试的阈值浓度和ROAT的结果之间发现相关性。 ROAT的反应性差异很大。评估ROAT反应的客观措施除视觉评估外没有其他信息。

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