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首页> 外文期刊>Acta Dermato-Venereologica >HPV prevalence in anal warts tested with the MY09/MY11 SHARP Signal system.
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HPV prevalence in anal warts tested with the MY09/MY11 SHARP Signal system.

机译：使用MY09 / MY11 SHARP信号系统测试的肛门疣中的HPV患病率。

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摘要

Anal warts are, from an aetiological point of view, a diverse category of lesions including condylomata acuminata, fibroepithelial polyps and seborrhoeic keratosis. Human papillomavirus induced anal warts, in contrast to other types of warts, are contagious and not infrequently sexually transmitted, they therefore need to be accurately identified. A total of 24 anal warts were randomly collected and the histopathological diagnoses based on microscopy, alone or in combination with a sensitive PCR-based human papillomavirus test, were compared using the SHARP Signal system for detection. Three lesions were identified as condyloma acuminatum by morphology alone due to the obvious presence of koiloytotic atypia; 11 warts without koilocytes were identified only after a positive test for anogenital human papillomavirus. One additional lesion contained human papillomavirus DNA of cutaneous type and 9 papillomas were human papillomavirus-negative and tentatively diagnosed as fibroepithelial polyps or seborrhoeic keratosis. All 14 condylomas contained human papillomavirus of low-risk type. Of these, 12 warts showed a positive human papillomavirus reaction with in situ hybridization. Morphology alone cannot reveal the true nature of most anal papillomas, even when koilocytotic atypia is considered as a diagnostic hallmark. An optimal diagnosis of anal warts requires a sensitive PCR-based human papillomavirus DNA test. A test for identification of cutaneous human papillomavirus DNA is also worthwhile.
机译：从病因学的角度来看，肛门疣是多种病变，包括尖锐湿疣，纤维上皮息肉和脂溢性角化病。与其他类型的疣不同，人乳头瘤病毒引起的肛门疣具有传染性，并且很少通过性传播，因此需要准确识别。随机收集总共24个肛门疣，并使用SHARP Signal系统对单独或结合基于PCR的敏感人类乳头瘤病毒测试的显微镜下组织病理学诊断进行比较。由于存在明显的胆管细胞异型性，仅通过形态学就将三个病变确定为尖锐湿疣。仅在对生殖器人乳头瘤病毒进行了阳性试验后，才鉴定出11种没有幼稚细胞的疣。另外一个病灶包含皮肤类型的人乳头瘤病毒DNA，并且9个乳头状瘤为人乳头瘤病毒阴性，并初步诊断为纤维上皮息肉或脂溢性角化病。所有14个con状瘤均包含低危型人乳头瘤病毒。在这些疣中，有12个疣表现出人乳头瘤病毒与原位杂交呈阳性反应。即使仅以形态细胞学为特征的诊断，仅靠形态学也无法揭示大多数肛门乳头状瘤的真实本质。肛门疣的最佳诊断需要基于PCR的敏感人乳头瘤病毒DNA检测。鉴定人皮肤乳头瘤病毒DNA的测试也是值得的。

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