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首页> 外文期刊>Acta biomaterialia >Effect of hydroxyapatite on the biodegradation and biomechanical stability of polyester nanocomposites for orthopaedic applications.
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Effect of hydroxyapatite on the biodegradation and biomechanical stability of polyester nanocomposites for orthopaedic applications.

机译：羟基磷灰石对骨科应用聚酯纳米复合材料生物降解和生物力学稳定性的影响。

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摘要

The effect of hydroxyapatite (HAP) on the performance of nanocomposites of an unsaturated polyester, i.e., hydroxy-terminated high molecular weight poly(proplyene fumarate) (HT-PPFhm), was investigated. A thermoset nanocomposite was prepared with nanoparticles of calcined HAP (<100 nm, rod-like shape, filler content 30 wt.%), HT-PPFhm and N-vinyl pyrrolidone, dibenzoyl peroxide and N,N-dimethyl aniline. Two more nanocomposites were prepared with precipitated HAP nanoparticles (<100 nm rod-like shape) and commercially available HAP nanoparticles (<200 nm spherical shape), respectively. Calcined HAP nanoparticles resulted in very good crosslinking in the resin matrix with high crosslinking density and interfacial bonding with the polymer, owing to the rod-like shape of the nanoparticles; this gave improved biomechanical strength and modulus and also controlled degradation of the nanocomposite for scaffold formation. The tissue compatibility and osteocompatibility of the nanocomposite containing calcined HAP nanoparticles was evaluated. The tissue compatibility was studied by intramuscular implantation in a rabbit animal model for 3 months as per ISO standard 10993/6. The in vivo femoral bone repair was also carried out in the rabbit animal model as per ISO standard 10993/6. The nanocomposite containing calcined HAP nanoparticles is both biocompatible and osteocompatible.
机译：研究了羟基磷灰石（HAP）对不饱和聚酯纳米复合材料（即羟基封端的高分子量聚富马酸丙二醇酯（HT-PPFhm））的性能的影响。用煅烧的HAP（＜100nm，棒状，填料含量为30重量％），HT-PPFhm和N-乙烯基吡咯烷酮，过氧化二苯甲酰和N，N-二甲基苯胺的纳米颗粒制备热固性纳米复合材料。分别用沉淀的HAP纳米颗粒（<100 nm棒状）和市售的HAP纳米颗粒（<200 nm球形）制备了另外两种纳米复合材料。煅烧的HAP纳米颗粒由于呈纳米棒状，因此在树脂基质中具有非常好的交联性，具有高的交联密度和与聚合物的界面键;这提供了改善的生物力学强度和模量，并且还控制了用于支架形成的纳米复合材料的降解。评价了包含煅烧的HAP纳米颗粒的纳米复合材料的组织相容性和骨相容性。根据ISO标准10993/6，通过肌内植入兔动物模型中3个月来研究组织相容性。还按照ISO标准10993/6在兔动物模型中进行了股骨的体内修复。包含煅烧的HAP纳米颗粒的纳米复合材料既具有生物相容性又具有骨相容性。

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