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首页> 外文期刊>Acta biomaterialia >Porous bioactive diopside (CaMgSi(2)O(6)) ceramic microspheres for drug delivery.
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Porous bioactive diopside (CaMgSi(2)O(6)) ceramic microspheres for drug delivery.

机译：多孔生物活性透辉石（CaMgSi（2）O（6））陶瓷微球用于药物输送。

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摘要

Ideal bioceramic microspheres for bone regeneration need to be bioactive and degradable, but at the same time possess a controlled drug-release ability. The main disadvantage of the currently available microspheres is their failure to combine these properties. The aim of this study is to develop bioactive ceramic microspheres with optimal properties for use in bone-tissue regeneration. In this study, we utilize diopside (CaMgSi(2)O(6), DP) with proven excellent bioactivity and degradation ability to develop microspheres by controlling their porosity and size, and further modify their surface with polymer to enhance and control their drug-loading/release ability. The phase composition, surface and inner microstructure, and porosity of DP microspheres were tested. Results indicate that carbon powders as porogens with various contents determined the porosity of the porous DP microspheres. The drug-loading and release ability of dexamethazone (DEX) from porous DP microspheres was regulated by their porosity and size. Poly(lactide-co-glycolide) modification forms a film on the surface of DP microspheres and resulted in an enhanced DEX-loading and release ability of the microspheres. Results presented here indicate that the developed DP microspheres have the potential to be used as bioactive filling materials for bone-tissue regeneration.
机译：理想的用于骨再生的生物陶瓷微球必须具有生物活性和可降解性，但同时具有受控的药物释放能力。当前可用的微球的主要缺点是它们不能结合这些性质。这项研究的目的是开发具有最佳特性的生物活性陶瓷微球，用于骨组织再生。在这项研究中，我们利用透辉石（CaMgSi（2）O（6），DP）证明具有出色的生物活性和降解能力，可通过控制其孔隙度和大小来开发微球，并进一步利用聚合物修饰其表面以增强和控制其药物-加载/释放能力。测试了DP微球的相组成，表面和内部微结构以及孔隙率。结果表明，作为致孔剂的碳粉含量各异，决定了多孔DP微球的孔隙率。地塞米松（DEX）从多孔DP微球的载药和释放能力受其孔隙度和大小的调节。聚（丙交酯-共-乙交酯）改性在DP微球表面形成薄膜，并提高了微球的DEX负载和释放能力。此处显示的结果表明，已开发的DP微球具有用作骨组织再生的生物活性填充材料的潜力。

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