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首页> 外文期刊>Acta biomaterialia >Blood compatibility of photografted hydrogel coatings.
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Blood compatibility of photografted hydrogel coatings.

机译：光接枝水凝胶涂层的血液相容性。

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摘要

In this work, we have evaluated the haemocompatibility of different surface modifications, intended for biomaterials and bioanalytical applications. Polystyrene slides were coated with thin hydrogel films by self-initiated photografting and photopolymerization (SIPGP) of four different monomers. The hydrogel surface modifications were thoroughly characterized and tested for their protein resistance and ability to resist platelet adhesion and activation of the coagulation system. There was very little protein adsorption from human plasma on the hydrogels prepared from poly(ethylene glycol) methacrylate and 2-hydroxyethyl methacrylate. Platelet adhesion tests performed under both static and flow conditions showed that these coatings also demonstrated very high resistance towards platelet adhesion. A small amount of platelets were found to adhere to hydrogels formed from ethylene glycol methyl ether methacrylate and 2-carboxyethyl methacrylate. The polystyrene substrates themselves facilitated large amounts of platelet adhesion under both static and flow conditions. Utilizing a novel setup for imaging of coagulation, it was confirmed that none of the hydrogel surfaces activated the coagulation system to any great extent. We suggest that this simple fabrication method can be used to produce hydrogel coatings with unusually high blood compatibility, suitable for demanding biomaterials applications.
机译：在这项工作中，我们评估了用于生物材料和生物分析应用的不同表面改性的血液相容性。聚苯乙烯载玻片通过四种不同单体的自引发光接枝和光聚合（SIPGP）涂上水凝胶薄膜。对水凝胶表面修饰物进行了全面表征，并测试了其蛋白质抗性以及抗血小板粘附和凝血系统活化的能力。在聚甲基丙烯酸乙二醇酯和甲基丙烯酸2-羟乙酯制备的水凝胶上，人血浆中几乎没有蛋白质吸附。在静态和流动条件下进行的血小板粘附测试表明，这些涂层还显示出非常高的抗血小板粘附性。发现少量血小板粘附于由乙二醇甲基甲基丙烯酸甲酯和甲基丙烯酸2-羧乙酯形成的水凝胶。聚苯乙烯基质本身在静态和流动条件下都促进了大量的血小板粘附。利用用于凝结成像的新颖装置，证实了水凝胶表面均未在任何程度上激活凝结系统。我们建议这种简单的制造方法可用于生产具有异常高血液相容性的水凝胶涂层，适用于要求苛刻的生物材料应用。

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