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首页> 外文期刊>Acta biomaterialia >Foamed surfactant solution as a template for self-setting injectable hydroxyapatite scaffolds for bone regeneration.
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Foamed surfactant solution as a template for self-setting injectable hydroxyapatite scaffolds for bone regeneration.

机译：发泡表面活性剂溶液作为模板，用于自固化可注射的羟基磷灰石支架，用于骨骼再生。

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The application of minimally invasive surgical techniques in the field of orthopaedic surgery has created a growing need for new injectable synthetic materials that can be used for bone grafting. In this work a novel fully synthetic injectable calcium phosphate foam was developed by mixing alpha-tricalcium phosphate (alpha-TCP) powder with a foamed polysorbate 80 solution. Polysorbate 80 is a non-ionic surfactant approved for parenteral applications. The foam was able to retain the porous structure after injection provided that the foamed paste was injected shortly after mixing (typically 2.5 min), and set through the hydrolysis of alpha-TCP to a calcium-deficient hydroxyapatite, thus producing a hydroxyapatite solid foam in situ. The effect of different processing parameters on the porosity, microstructure, injectability and mechanical properties of the hydroxyapatite foams was analysed, and the ability of the pre-set foam to support osteoblastic-like cell proliferation and differentiation was assessed. Interestingly, the concentration of surfactant needed to obtain the foams was lower than that considered safe in drug formulations for parenteral administration. The possibility of combining bioactivity, injectability, macroporosity and self-setting ability in a single fully synthetic material represents a step forward in the design of new materials for bone regeneration compatible with minimally invasive surgical techniques.
机译：在骨外科领域中，微创外科技术的应用引起了对可用于骨移植的新型可注射合成材料的日益增长的需求。在这项工作中，通过将α-磷酸三钙（α-TCP）粉末与泡沫聚山梨酯80溶液混合，开发了一种新型的全合成可注射磷酸钙泡沫。聚山梨酯80是批准用于肠胃外应用的非离子表面活性剂。泡沫在注入后能够保留多孔结构，条件是混合后不久（通常为2.5分钟）注入泡沫糊，并通过将α-TCP水解为缺钙的羟基磷灰石而固化，从而制得羟基磷灰石固体泡沫。原地。分析了不同工艺参数对羟基磷灰石泡沫材料的孔隙率，微观结构，可注射性和力学性能的影响，并评估了预设泡沫材料支持成骨细胞样细胞增殖和分化的能力。有趣的是，获得泡沫所需的表面活性剂浓度低于肠胃外给药药物制剂中认为安全的浓度。在单一完全合成的材料中结合生物活性，可注射性，大孔性和自定型能力的可能性，代表了与微创外科技术兼容的骨再生新材料设计的进步。

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