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首页> 外文期刊>Acta biomaterialia >Nano-controlled molecular interaction at adhesive interfaces for hard tissue reconstruction.
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Nano-controlled molecular interaction at adhesive interfaces for hard tissue reconstruction.

机译：用于硬组织重建的粘合剂界面处的纳米控制分子相互作用。

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Although decayed/fractured teeth can be reconstructed minimally invasively and nearly invisibly using adhesive technology, the clinical longevity of dental composite restorations is still too short. Water sorption is thought to be the principal cause of destabilization of the biomaterial-tooth bond. However, the actual mechanisms of interfacial degradation are far from understood. Here we report how nano-controlled molecular interaction at the biomaterial-hard tissue interface can improve bond durability. The use of functional monomers with a strong chemical affinity for the calcium in hydroxyapatite is essential for long-term durability. Correlative X-ray diffraction and solid-state nuclear magnetic resonance disclosed a time-dependent molecular interaction at the interface with stable ionic bond formation of the monomer to hydroxyapatite competing in time with the deposition of less stable calcium phosphate salts. The advanced tooth-biomaterial interaction model gives not only an insight into the mechanisms of bond degradation, but also provides a basis to develop functional monomers for more durable tooth reconstruction.
机译：尽管可以使用粘合技术以微创和几乎不可见的方式重建腐烂/折断的牙齿，但牙科复合材料修复体的临床寿命仍然太短。人们认为吸水是生物材料-牙齿键不稳定的主要原因。但是，界面降解的实际机理还远未弄清楚。在这里，我们报告在生物材料-硬组织界面处的纳米控制分子相互作用如何提高键的耐久性。对于羟基磷灰石中的钙，使用对钙具有强化学亲和力的功能性单体对于长期耐久性至关重要。相关的X射线衍射和固态核磁共振揭示了在界面上的时间依赖性分子相互作用，其中单体与羟基磷灰石之间形成稳定的离子键，与沉积不太稳定的磷酸钙盐及时竞争。先进的牙齿与生物材料的相互作用模型不仅提供了对键降解机理的深入了解，而且还为开发功能单体以实现更持久的牙齿重建提供了基础。

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