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首页> 外文期刊>Acta biomaterialia >Synthesis, characterization and cytotoxicity of photo-crosslinked maleic chitosan-polyethylene glycol diacrylate hybrid hydrogels.
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Synthesis, characterization and cytotoxicity of photo-crosslinked maleic chitosan-polyethylene glycol diacrylate hybrid hydrogels.

机译：光交联的马来酸壳聚糖-聚乙二醇二丙烯酸酯杂化水凝胶的合成，表征和细胞毒性。

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摘要

Synthetic hydrogels are important biomaterials for many biomedical applications and hydrogels produced via photo-gelation have shown particular promise. In this paper, we describe a new family of biodegradable hybrid hydrogels fabricated in aqueous solution via long wavelength UV photo-crosslinking using maleic chitosan and polyethylene glycol diacrylate (PEGDA) as precursors. The maleic chitosan precursor was prepared by a simple one-step chemical modification of chitosan, with high yields, and characterized by Fourier transform infrared spectroscopy, (1)H NMR and (13)C NMR. Maleic chitosan and PEGDA precursors at a wide range of weight feed ratios were mixed in aqueous solution and directly photo-crosslinked for 10 min under a long wavelength UV light (365 nm) using 4-(2-hydroxyethoxy) phenyl-(2-hydroxy-2-propyl) ketone (Irgacure 2959) as photoinitiator. It was observed that as the weight feed ratio of maleic chitosan to PEGDA decreased the pore sizes of the hydrogel samples decreased, thereby increasing the densities of the hydrogel networks and producing a lower swelling ratio and a higher compressive modulus. The molecular weight of PEGDA had a similar effect. Preliminary cell cytotoxicity tests of both the maleic chitosan precursor and maleic chitosan/PEGDA hydrogels, based on the MTT assay and live-dead assay, respectively, showed that these new chitosan-based biodegradable biomaterials were relatively non-toxic to bovine aortic endothelial cells at low dosages.
机译：合成水凝胶是许多生物医学应用中重要的生物材料，通过光凝胶化生产的水凝胶具有特别的前景。在本文中，我们描述了使用马来壳聚糖和聚乙二醇二丙烯酸酯（PEGDA）作为前体，通过长波长UV光交联在水溶液中制备的新的可生物降解的杂化水凝胶家族。通过简单的一步法对壳聚糖进行化学修饰就可以高收率制备马来酸壳聚糖前体，并通过傅里叶变换红外光谱，（1）H NMR和（13）C NMR对其进行表征。将马来酸壳聚糖和PEGDA前体以宽的进料重量比混合在水溶液中，并使用4-（2-羟基乙氧基）苯基-（2-羟基）在长波长紫外线（365 nm）下直接光交联10分钟。 -2-丙基）酮（Irgacure 2959）作为光引发剂。观察到，随着马来壳聚糖与PEGDA的重量进料比降低，水凝胶样品的孔径减小，从而增加了水凝胶网络的密度，并产生了较低的溶胀率和较高的压缩模量。 PEGDA的分子量具有相似的作用。分别基于MTT分析和活死分析对马来壳聚糖前体和马来壳聚糖/ PEGDA水凝胶进行的初步细胞毒性测试表明，这些基于壳聚糖的新型可生物降解生物材料对牛主动脉内皮细胞无毒。低剂量。

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