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首页> 外文期刊>Acta biomaterialia >A three-layered electrospun matrix to mimic native arterial architecture using polycaprolactone, elastin, and collagen: a preliminary study.
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A three-layered electrospun matrix to mimic native arterial architecture using polycaprolactone, elastin, and collagen: a preliminary study.

机译：使用聚己内酯，弹性蛋白和胶原蛋白模拟天然动脉结构的三层电纺基质：初步研究。

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摘要

Throughout native artery, collagen, and elastin play an important role, providing a mechanical backbone, preventing vessel rupture, and promoting recovery under pulsatile deformations. The goal of this study was to mimic the structure of native artery by fabricating a multi-layered electrospun conduit composed of poly(caprolactone) (PCL) with the addition of elastin and collagen with blends of 45-45-10, 55-35-10, and 65-25-10 PCL-ELAS-COL to demonstrate mechanical properties indicative of native arterial tissue, while remaining conducive to tissue regeneration. Whole grafts and individual layers were analyzed using uniaxial tensile testing, dynamic compliance, suture retention, and burst strength. Compliance results revealed that changes to the middle/medial layer changed overall graft behavior with whole graft compliance values ranging from 0.8 to 2.8%/100 mm Hg, while uniaxial results demonstrated an average modulus range of 2.0-11.8 MPa. Both modulus and compliance data displayed values within the range of native artery. Mathematical modeling was implemented to show how changes in layer stiffness affect the overall circumferential wall stress, and as a design aid to achieve the best mechanical combination of materials. Overall, the results indicated that a graft can be designed to mimic a tri-layered structure by altering layer properties.
机译：在整个天然动脉中，胶原蛋白和弹性蛋白发挥重要作用，提供机械主干，防止血管破裂并促进搏动性变形下的恢复。这项研究的目的是通过制造由聚己内酯（PCL）组成的多层电纺导管，并添加弹性蛋白和胶原蛋白以及45-45-10、55-35-图10和65-25-10 PCL-ELAS-COL展示了指示天然动脉组织的机械性能，同时又有利于组织再生。使用单轴拉伸测试，动态柔度，缝合线保持力和破裂强度分析整个移植物和各个层。顺应性结果显示，中间/中间层的变化改变了整体移植物的行为，整个移植物顺应性值的范围为0.8至2.8％/ 100 mm Hg，而单轴结果表明平均模量范围为2.0-11.8 MPa。模量和顺应性数据均显示天然动脉范围内的值。进行了数学建模，以显示层刚度的变化如何影响整体周向壁应力，并作为实现材料的最佳机械组合的设计辅助。总的来说，结果表明可以通过改变层的性质来设计移植物以模仿三层结构。

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