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首页> 外文期刊>Acta biomaterialia >Premature degradation of poly(alpha-hydroxyesters) during thermal processing of Bioglass-containing composites.
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Premature degradation of poly(alpha-hydroxyesters) during thermal processing of Bioglass-containing composites.

机译：含生物玻璃的复合材料的热处理过程中，聚（α-羟基酯）会过早降解。

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Bioactive, biodegradable composites are increasingly being explored as bone replacement materials and as scaffolds for tissue engineering. Their properties are not only dependent on the properties of the filler and matrix, but are also determined by their interaction. This study investigated the effect on poly(D,L-lactide) (PDLLA) matrix when processed at high-temperatures in the presence of Bioglass particulate filler. Composites with different filler contents were compounded at elevated temperatures by co-extrusion followed by compression moulding and compared with composites of similar composition prepared by thermally induced phase separation (TIPS), a low-temperature processing route. It was found that the inclusion of Bioglass in PDLLA under elevated temperatures resulted in the degradation of the matrix, leading to a reduction in the mechanical properties of the composites and in the molecular weight of the matrix. Attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy showed the presence of a peak at 1600 cm(-1) in the composite material, particularly when processed at elevated temperatures, whereas no peak at this wavelength was discernible for the pure PDLLA. Furthermore, time-based ATR-FTIR spectra taken at elevated temperatures on the TIPS-processed composites showed an increase in the intensity of the peak at 1600 cm(-1) and a concomitant reduction of the CO stretch peak at 1745 cm(-1) with time. This suggested the formation of a carboxylate salt by-products as a consequence of a reaction at the interface between the Bioglass filler and the PDLLA matrix. Therefore, the results confirmed that this degradation was not solely due to shear effects during the extrusion process. This work thereby supports the assertion that, in the presence of Bioglass filler particles, poly(alpha-hydroxyester)-based composites should not be processed at elevated temperatures.
机译：具有生物活性的，可生物降解的复合材料正越来越多地被用作骨替代材料和组织工程的支架。它们的性质不仅取决于填料和基质的性质，而且还取决于它们的相互作用。这项研究调查了在有生物玻璃颗粒填料存在的情况下在高温下对聚（D，L-丙交酯）（PDLLA）基质的影响。将具有不同填料含量的复合材料在高温下通过共挤出复合材料进行压塑，然后与通过低温加工路线热诱导相分离（TIPS）制备的相似组成的复合材料进行比较。发现在升高的温度下PDLLA中包含生物玻璃导致基质的降解，导致复合材料的机械性能和基质分子量的降低。衰减全反射傅里叶变换红外（ATR-FTIR）光谱显示复合材料中在1600 cm（-1）处存在一个峰，尤其是在高温下处理时，而对于纯PDLLA，在此波长下没有可辨别的峰。此外，在高温下对TIPS处理的复合材料进行的基于时间的ATR-FTIR光谱显示，在1600 cm（-1）处的峰强度增加，并且在1745 cm（-1）处的CO拉伸峰随之降低） 随着时间的推移。这表明由于生物玻璃填料和PDLLA基质之间的界面反应，形成了羧酸盐副产物。因此，结果证实了这种降解不仅是由于挤出过程中的剪切效应。因此，这项工作支持这样的主张，即在存在生物玻璃填料颗粒的情况下，不应在高温下加工基于聚（α-羟基酯）的复合材料。

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