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首页> 外文期刊>Acta biomaterialia >Influence of porosity on mechanical properties and in vivo response of Ti6Al4V implants.
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Influence of porosity on mechanical properties and in vivo response of Ti6Al4V implants.

机译：孔隙率对Ti6Al4V植入物的力学性能和体内响应的影响。

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摘要

Metallic biomaterials are widely used to restore the lost structure and functions of human bone. Due to the large number of joint replacements, there is a growing demand for new and improved orthopedic implants. More specifically, there is a need for novel load-bearing metallic implants with low effective modulus matching that of bone in order to reduce stress shielding and consequently increase the in vivo lifespan of the implant. In this study, we have fabricated porous Ti6Al4V alloy structures, using laser engineered net shaping (LENS), to demonstrate that advanced manufacturing techniques such as LENS can be used to fabricate low-modulus, tailored porosity implants with a wide variety of metals/alloys, where the porosity can be designed in areas based on the patient's need to enhance biological fixation and achieve long-term in vivo stability. The effective modulus of Ti6Al4V alloy structures has been tailored between 7 and 60 GPa and porous Ti alloy structures containing 23-32 vol.% porosity showed modulus equivalent to human cortical bone. In vivo behavior of porous Ti6Al4V alloy samples in male Sprague-Dawley rats for 16 weeks demonstrated a significant increase in calcium within the implants, indicating excellent biological tissue ingrowth through interconnected porosity. In vivo results also showed that total amount of porosity plays an important role in tissue ingrowth.
机译：金属生物材料被广泛用于恢复人骨丢失的结构和功能。由于关节置换的数量众多，因此对新型和改良的骨科植入物的需求不断增长。更具体地，需要具有与骨头的有效模量低的有效模量的新型承重金属植入物，以减少应力屏蔽并因此增加植入物的体内寿命。在这项研究中，我们使用激光工程网成形（LENS）制造了多孔Ti6Al4V合金结构，以证明先进的制造技术（例如LENS）可用于制造具有多种金属/合金的低模量，量身定制的孔隙率植入物可以根据患者的需要设计区域的孔隙率，以增强生物固定并实现长期的体内稳定性。 Ti6Al4V合金结构的有效模量已调整为7 GPa至60 GPa之间，而孔隙率为23-32％（体积）的多孔Ti合金结构的模量与人体皮质骨相当。在雄性Sprague-Dawley大鼠中，多孔Ti6Al4V合金样品的体内行为16周表明，植入物中的钙含量显着增加，表明通过相互连接的孔隙率，生物组织向内生长极佳。体内结果还表明，孔隙总量在组织向内生长中起重要作用。

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