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首页> 外文期刊>Acta biomaterialia >In vivo performance of absorbable collagen sponges with rosuvastatin in critical-size cortical bone defects.
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In vivo performance of absorbable collagen sponges with rosuvastatin in critical-size cortical bone defects.

机译：具有瑞舒伐他汀的可吸收胶原蛋白海绵在体内的临界尺寸皮质骨缺损的体内性能。

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Rosuvastatin (RSV) is a synthetic statin with favourable pharmacologic properties, but its local effect in bone has yet to be investigated. The aim of this study was to evaluate the potential of absorbable collagen sponge (ACS) as a carrier for RSV to enhance bone formation in critical-size cortical bone defects adjacent to titanium implants. ACS, treated with different concentrations of RSV (R1 = 8.7 + or - 1.8 microg; R2 = 52.0 + or - 4.4 microg; R3 = 259.1 + or - 8.8 microg) or phosphate-buffered saline alone, were placed into the bone marrow through a defect made in the proximal tibial cortical bone of New Zealand White rabbits. One empty defect (SHAM) served as an internal control in each animal. After a healing time of 4 weeks, a concentration-dependent increase of alkaline phosphatase activity in ACS treated with RSV was detected in the bone fluid after removing the implants. In addition, a significant concentration-dependent increase in BMP-2 mRNA levels was found in the cortical bone tissue adjacent to the RSV-treated ACS. The cortical architecture of bone defects analysed by micro-computed tomography showed a trend towards higher bone volume in the ACS+R1 group compared with SHAM, which was accompanied by an increase in the bone mineral density. Evaluation of histological sections showed new bone formation in ACS treated with RSV but not in untreated ACS. These results indicate that RSV, when administered locally in bone, may have a potential effect in stimulating bone formation.
机译：罗苏伐他汀（RSV）是一种合成的他汀类药物，具有良好的药理特性，但其在骨中的局部作用尚待研究。这项研究的目的是评估可吸收胶原蛋白海绵（ACS）作为RSV载体增强钛植入物附近的临界大小皮质骨缺损中骨形成的潜力。将单独用不同浓度的RSV（R1 = 8.7 +或-1.8微克; R2 = 52.0 +或-4.4微克; R3 = 259.1 +或-8.8微克）或磷酸盐缓冲液处理的ACS通过以下方法放入骨髓中新西兰白兔胫骨近端皮质骨的缺损。每个动物中有一个空缺（SHAM）作为内部对照。修复4周后，在去除植入物后，在骨液中检测到经RSV处理的ACS中碱性磷酸酶活性的浓度依赖性增加。此外，在与RSV处理的ACS相邻的皮质骨组织中发现BMP-2 mRNA的浓度依赖性显着增加。通过微计算机断层扫描分析的骨缺损的皮质结构显示，与SHAM相比，ACS + R1组的骨体积有增加的趋势，同时伴有骨矿物质密度的增加。组织切片的评估显示在用RSV治疗的ACS中新的骨形成，但在未治疗的ACS中没有。这些结果表明，当在骨中局部施用RSV时，可能具有刺激骨形成的潜在作用。

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