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首页> 外文期刊>Acta biomaterialia >Optimization of the structure of polyurethanes for bone tissue engineering applications.
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Optimization of the structure of polyurethanes for bone tissue engineering applications.

机译：用于骨组织工程应用的聚氨酯结构的优化。

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摘要

Polyurethanes containing 22-70 wt.% hard segments were developed and evaluated for bone tissue engineering applications. Aliphatic poly(ester-urethanes) were synthesised from poly(epsilon-caprolactone) diol with different molecular masses (M= approximately 530, 1250 and 2000 Da), cycloaliphatic diisocyanate 4,4'-methylenebis(cyclohexyl isocyanate) and ethylene glycol as a chain extender. Changes in macromolecule order with increasing hard segment content were observed via modulated differential scanning calorimetry. Depending on the hard segment content, a gradual variation in polyurethane surface properties was revealed by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and static contact angle measurements. As the hard segments content increased the polyurethane surface exhibited more phase separation, a higher content of urethane moieties and higher hydrophilicity. The biocompatibility results indicated that proliferation of human bone-derived cells (HBDC) cultured in vitro improved with increasing hard segment content while the osteogenic potential of HBDC decreased with increasing hard segment content.
机译：开发了含有22-70 wt。％硬链段的聚氨酯，并对其进行了骨组织工程应用评估。由具有不同分子量（M = 530、1250和2000 Da）的聚（ε-己内酯）二醇，脂环族二异氰酸酯4,4'-亚甲基双（环己基异氰酸酯）和乙二醇合成脂肪族聚（酯-氨基甲酸酯）扩链剂。通过调制差示扫描量热法观察到大分子顺序随硬链段含量的增加而变化。取决于硬链段的含量，通过傅立叶变换红外光谱，X射线光电子能谱和静态接触角测量揭示了聚氨酯表面性能的逐渐变化。随着硬链段含量的增加，聚氨酯表面表现出更多的相分离，更高的氨基甲酸酯部分含量和更高的亲水性。生物相容性结果表明，体外培养的人骨来源细胞（HBDC）的增殖随着硬段含量的增加而改善，而HBDC的成骨潜力随着硬段含量的增加而降低。

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