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首页> 外文期刊>Acta biomaterialia >In vitro and in vivo comparisons of staphylococcal biofilm formation on a cross-linked poly(ethylene glycol)-based polymer coating.
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In vitro and in vivo comparisons of staphylococcal biofilm formation on a cross-linked poly(ethylene glycol)-based polymer coating.

机译：在交联的基于聚乙二醇的聚合物涂层上葡萄球菌生物膜形成的体外和体内比较。

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摘要

Poly(ethylene glycol) (PEG) coatings are known to reduce microbial adhesion in terms of numbers and binding strength. However, bacterial adhesion remains of the order of 10(4)cm(-2). It is unknown whether this density of bacteria will eventually grow into a biofilm. This study investigates the kinetics of staphylococcal biofilm formation on a commercially produced, robust, cross-linked PEG-based polymer coating (OptiChem) in vitro and in vivo. OptiChem inhibits biofilm formation in vitro, and although adsorption of plasma proteins encourages biofilm formation, microbial growth kinetics are still strongly delayed compared to uncoated glass. In vivo, OptiChem-coated and bare silicone rubber samples were inserted into an infected murine subcutaneous pocket model. In contrast to bare silicone rubber, OptiChem samples did not become colonized upon reimplantation despite the fact that surrounding tissues were always culture-positive. We conclude that the commercial OptiChem coating considerably slows down bacterial biofilm formation both in vitro and in vivo, making it an attractive candidate for biomaterials implant coating.
机译：已知聚（乙二醇）（PEG）涂层在数量和结合强度方面降低微生物粘附。但是，细菌粘附保持在10（4）cm（-2）的数量级。尚不清楚这种细菌密度是否最终会长成生物膜。这项研究调查了在体外和体内商业生产的，坚固的，交联的基于PEG的聚合物涂层（OptiChem）上葡萄球菌生物膜形成的动力学。 OptiChem可以在体外抑制生物膜的形成，尽管血浆蛋白的吸附会促进生物膜的形成，但与未镀膜的玻璃相比，微生物的生长动力学仍然强烈延迟。在体内，将OptiChem涂层的裸硅橡胶样品插入感染的鼠皮下口袋模型中。与裸露的硅橡胶相比，尽管周围组织始终是培养阳性的事实，但OptiChem样品在重新植入后并未定植。我们得出的结论是，商用OptiChem涂层在体外和体内均可大大减慢细菌生物膜的形成，使其成为生物材料植入物涂层的有吸引力的候选者。

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