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首页> 外文期刊>Acta biomaterialia >Hydroxyapatite nanorods/poly(vinyl pyrolidone) composite nanofibers, arrays and three-dimensional fabrics: electrospun preparation and transformation to hydroxyapatite nanostructures.
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Hydroxyapatite nanorods/poly(vinyl pyrolidone) composite nanofibers, arrays and three-dimensional fabrics: electrospun preparation and transformation to hydroxyapatite nanostructures.

机译：羟基磷灰石纳米棒/聚乙烯吡咯烷酮复合纳米纤维，阵列和三维织物：电纺丝制备并转变为羟基磷灰石纳米结构。

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摘要

Electrospinning has been recognized as an efficient technique for fabricating polymer nanofibrous biomaterials. However, the study of electrospun inorganic biomaterials with well-designed three-dimensional (3-D) structures is still limited and little reported. In this study hydroxyapatite (HAp) nanorods with an average diameter of approximately 7 nm and length of approximately 27 nm were synthesized through a simple precipitation method and used for the fabrication of inorganic/organic [poly(vinyl pyrolidone) (PVP)] composite nanofibers by electrospinning in ethanol solution. 3-D fabrics and aligned nanofiber arrays of the HAp nanorods/PVP composite were obtained as precursors. Thereafter, 3-D single phase HAp fabrics, tubular structures and aligned nanofiber arrays were obtained after thermal treatment of the corresponding composite precursors. Cytotoxicity experiments indicated that the HAp fabric scaffold had good biocompatibility. In vitro experiments showed that mesenchymal stem cells could attach to the HAp fabric scaffold after culture for 24h.
机译：电纺丝已被认为是制造聚合物纳米纤维生物材料的有效技术。然而，对具有精心设计的三维（3-D）结构的电纺无机生物材料的研究仍然是有限的，很少有报道。在这项研究中，通过简单的沉淀方法合成了平均直径约为7 nm，长度约为27 nm的羟磷灰石（HAp）纳米棒，并用于制造无机/有机[聚乙烯吡咯烷酮（PVP）]复合纳米纤维。通过在乙醇溶液中静电纺丝。获得了HAp纳米棒/ PVP复合材料的3-D织物和对齐的纳米纤维阵列作为前体。此后，在对相应的复合前体进行热处理之后，获得了3-D单相HAp织物，管状结构和对齐的纳米纤维阵列。细胞毒性实验表明，HAp织物支架具有良好的生物相容性。体外实验表明，培养24h后，间充质干细胞可以附着在HAp织物支架上。

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