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首页> 外文期刊>Acta biomaterialia >Pyrrole-hyaluronic acid conjugates for decreasing cell binding to metals and conducting polymers.
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Pyrrole-hyaluronic acid conjugates for decreasing cell binding to metals and conducting polymers.

机译：吡咯-透明质酸结合物，用于减少细胞与金属的结合并传导聚合物。

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Surface modification of electrically conductive biomaterials has been studied to improve biocompatibility for a number of applications, such as implantable sensors and microelectrode arrays. In this study we electrochemically coated electrodes with biocompatible and non-cell adhesive hyaluronic acid (HA) to reduce cellular adhesion for potential use in neural prostheses. To this end, pyrrole-conjugated hyaluronic acid (PyHA) was synthesized and employed to electrochemically coat platinum, indium-tin oxide and polystyrene sulfonate-doped polypyrrole electrodes. This PyHA conjugate consisted of (1) a pyrrole moiety that allowed the compound to be electrochemically polymerized onto a conductive substrate and (2) non-adhesive HA to minimize cell adhesion and to potentially decrease inflammatory tissue responses. Our characterization results showed the presence of a hydrophilic p(PyHA) layer on the modified electrode, and impedance measurements revealed an impedance that was statistically the same as the unmodified electrode. We found that the p(PyHA)-coated electrodes minimized adhesion and migration of fibroblasts and astrocytes for a minimum of up to 3 months. Also, the coating was stable in physiological solution for 3 months and was stable against enzymatic degradation by hyaluronidase. These studies suggest that this p(PyHA) coating has the potential to be used to mask conducting electrodes from adverse glial responses that occur upon implantation. In addition, electrochemical coating with PyHA could potentially be extended for the surface modification of other metallic and conducting substances, such as stents and biosensors.
机译：已经对导电生物材料的表面改性进行了研究，以提高其在许多应用中的生物相容性，例如可植入传感器和微电极阵列。在这项研究中，我们用生物相容性和非细胞粘附性透明质酸（HA）电化学涂覆了电极，以减少细胞粘附性，可用于神经假体。为此，合成了吡咯共轭的透明质酸（PyHA），并用于电化学涂覆铂，氧化铟锡和掺杂聚苯乙烯磺酸盐的聚吡咯电极。该PyHA共轭物由（1）使化合物电化学聚合到导电基质上的吡咯部分和（2）非粘合HA组成，以最大程度地减少细胞粘附并潜在地降低炎症组织反应。我们的表征结果表明，在改性电极上存在亲水性p（PyHA）层，而阻抗测量表明其阻抗在统计学上与未改性电极相同。我们发现，p（PyHA）涂层的电极可将成纤维细胞和星形胶质细胞的粘附和迁移减至最少3个月。而且，该涂层在生理溶液中稳定3个月，并且对于透明质酸酶的酶促降解是稳定的。这些研究表明，这种p（PyHA）涂层有潜力用于掩盖导电电极，使其免受植入后发生的不良神经胶质反应的影响。此外，PyHA的电化学涂层可能会扩展到其他金属和导电物质的表面改性，例如支架和生物传感器。

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