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首页> 外文期刊>Acta biomaterialia >Characterization of the mechanical properties of the coronary sinus for percutaneous transvenous mitral annuloplasty.
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Characterization of the mechanical properties of the coronary sinus for percutaneous transvenous mitral annuloplasty.

机译：经皮经皮二尖瓣瓣环成形术的冠状窦机械特性的表征。

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摘要

The coronary sinus (CS) vessel serves as a conduit for the deployment of percutaneous transvenous mitral annuloplasty (PTMA) devices for the treatment of functional mitral regurgitation. Characterization of the mechanical response of the CS is an important step towards an understanding of tissue-device interaction in PTMA intervention. The purpose of this study was to investigate the mechanical properties of the porcine CS using the pressure-inflation test and constitutively model the wall behavior using a four fiber family strain energy function (SEF). The results showed that the CS exhibited an S-shaped pressure-radius response and could be dilated up to 88% at a pressure of 80mmHg. Excellent results from model fitting indicated that the four fiber family SEF could capture the experimental data well and could be used in future numerical simulations of tissue-device interaction. In addition, a histological study was performed to identify the micro-structure of the CS wall. We found a high content of striated myocardial fibers (SMFs) surrounding the CS wall, which was also mainly composed of SMFs, while the content of smooth muscle cells was very low. Elastin and collagen fibers were highly concentrated in the luminal and outer layers and sparsely distributed in the medial layer of the CS wall. These structural and mechanical properties of the CS should be taken into consideration in future PTMA device designs.
机译：冠状窦（CS）血管用作导管，用于部署经皮二尖瓣瓣环成形术（PTMA）设备，以治疗功能性二尖瓣反流。 CS的机械反应的表征是迈向了解PTMA干预中组织-设备相互作用的重要一步。这项研究的目的是使用压力充气试验研究猪CS的机械性能，并使用四纤维族应变能函数（SEF）来本构模型地模拟壁的行为。结果表明，CS表现出S形的压力半径响应，并且在80mmHg的压力下可以扩展到88％。模型拟合的优异结果表明，四纤维SEF可以很好地捕获实验数据，并且可以用于将来的组织－设备相互作用的数值模拟。另外，进行了组织学研究以鉴定CS壁的微观结构。我们发现CS壁周围的横纹肌纤维（SMFs）含量很高，其也主要由SMF组成，而平滑肌细胞的含量却很低。弹性蛋白和胶原纤维高度集中在管腔和外层，稀疏分布在CS壁的中间层。在将来的PTMA器件设计中，应考虑CS的这些结构和机械性能。

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