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首页> 外文期刊>Acta biomaterialia >Real-time measurements of coagulation on bacterial cellulose and conventional vascular graft materials.
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Real-time measurements of coagulation on bacterial cellulose and conventional vascular graft materials.

机译：细菌纤维素和常规血管移植材料上凝血的实时测量。

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摘要

The search for a functional, small diameter (<5mm) vascular graft has been ongoing for over 30 years, but yet there is no consistently reliable synthetic graft. The primary mechanisms of graft failure are intimal hyperplasia, poor blood flow and surface thrombogenicity. Bacterial cellulose (BC) became therefore a proposed new biosynthetic vascular graft material. Since conventional methods are not suited for coagulation measurements on BC, we have adapted the automated calibrated thrombin generation method for measurements of biomaterial-induced coagulation of BC as compared with clinically used graft materials i.e., expanded poly(tetrafluoroethylene) (ePTFE) and poly(ethyleneterephtalat) (PET). We have also visualized the coagulation propagation at the material surfaces. Thrombin generation experiments revealed dramatic differences between the materials tested. Both ePTFE and BC were found to generate longer lag times and ttpeak values than PET. Most importantly, BC was found to generate the lowest "peak", indicating a slower coagulation process at the surface. These results are also supported by the measurements of factor XIIa generation and analysis of surface coagulation times, which were detected in the following increasing order (mean + or - SD): PET (27 + or - 8 min)
机译：寻找功能性，小直径（<5mm）的血管移植物已经进行了30多年，但仍没有始终可靠的合成移植物。移植失败的主要机制是内膜增生，血液流动不良和表面血栓形成。因此细菌纤维素（BC）成为一种新的生物合成血管移植材料。由于常规方法不适合在BC上进行凝血测量，因此与临床使用的移植材料（即膨化聚四氟乙烯（ePTFE）和聚（四氟乙烯））相比，我们采用了自动校准的凝血酶生成方法来测量生物材料引起的BC凝血。乙烯对苯二甲酸）（PET）。我们还可视化了材料表面的凝结传播。凝血酶生成实验揭示了所测试材料之间的巨大差异。发现ePTFE和BC均比PET产生更长的滞后时间和ttpeak值。最重要的是，发现BC产生最低的“峰值”，表明表面的凝结过程较慢。这些结果也得到因子XIIa生成的测量和表面凝结时间的分析的支持，这些因子以下列递增顺序（平均值+或-SD）检测：PET（27 +或-8 min）

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