• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Synthesis, characterization and in vitro cell compatibility study of a poly(amic acid) graft/cross-linked poly(vinyl alcohol) hydrogel.
【24h】

Synthesis, characterization and in vitro cell compatibility study of a poly(amic acid) graft/cross-linked poly(vinyl alcohol) hydrogel.

机译：聚酰胺酸接枝/交联聚乙烯醇水凝胶的合成，表征和体外细胞相容性研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although physically cross-linked poly(vinyl alcohol) (PVA) hydrogels have tunable mechanical properties to match that of soft tissues, such as vascular tissue, their hydrophilic nature is not conducive to cell adhesion and spreading. For applications such as small diameter vascular grafts for coronary bypass both mechanical matching and hemocompatibility are important. Poly(amic acid) (PAA), derived from ethylene diamine tetraacetic dianhydride, is a cell-compatible polymer. It was grafted/cross-linked onto physically cross-linked PVA to provide cell compatibility. Functionalization was achieved via a one-step esterification reaction using 1,3-dicyclohexylcarbodiimide as the coupling agent and 4-dimethylaminopyridine as the catalyst. The success of the grafting reaction was verified using Fourier transform infrared spectroscopy, solid-state nuclear magnetic resonance spectroscopy and X-ray photoelectron spectroscopy. The mechanical properties of the starting PVA hydrogel were largely preserved after the grafting reaction within the physiological strain range of vascular tissue. In vitro cell culture studies using primary porcine endothelial cells confirmed cell compatibility of the PAA graft PVA hydrogel, making it an attractive candidate for small diameter vascular graft development.
机译：尽管物理交联的聚乙烯醇（PVA）水凝胶具有可调节的机械性能以匹配诸如血管组织之类的软组织的机械性能，但它们的亲水性不利于细胞粘附和扩散。对于诸如用于冠状动脉旁路的小直径血管移植物的应用，机械匹配和血液相容性均很重要。衍生自乙二胺四乙酸二酐的聚酰胺酸（PAA）是一种与细胞相容的聚合物。将其接枝/交联到物理交联的PVA上以提供细胞相容性。通过使用1，3-二环己基碳二亚胺作为偶联剂和4-二甲基氨基吡啶作为催化剂的一步酯化反应来实现官能化。使用傅里叶变换红外光谱，固态核磁共振光谱和X射线光电子能谱验证了接枝反应的成功。接枝反应后，在血管组织的生理应变范围内，很大程度上保留了起始PVA水凝胶的机械性能。使用原代猪内皮细胞进行的体外细胞培养研究证实了PAA移植PVA水凝胶的细胞相容性，使其成为小直径血管移植物发展的诱人候选人。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号