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首页> 外文期刊>Acta biomaterialia >Melt electrospinning of biodegradable polyurethane scaffolds.
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Melt electrospinning of biodegradable polyurethane scaffolds.

机译：可生物降解聚氨酯支架的熔融静电纺丝。

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摘要

Electrospinning from a melt, in contrast to from a solution, is an attractive tissue engineering scaffold manufacturing process as it allows for the formation of small diameter fibers while eliminating potentially cytotoxic solvents. Despite this, there is a dearth of literature on scaffold formation via melt electrospinning. This is likely due to the technical challenges related to the need for a well-controlled high-temperature setup and the difficulty in developing an appropriate polymer. In this paper, a biodegradable and thermally stable polyurethane (PU) is described specifically for use in melt electrospinning. Polymer formulations of aliphatic PUs based on (CH(2))(4)-content diisocyanates, polycaprolactone (PCL), 1,4-butanediamine and 1,4-butanediol (BD) were evaluated for utility in the melt electrospinning process. The final polymer formulation, a catalyst-purified PU based on 1,4-butane diisocyanate, PCL and BD in a 4/1/3M ratio with a weight-average molecular weight of about 40kDa, yielded a nontoxic polymer that could be readily electrospun from the melt. Scaffolds electrospun from this polymer contained point bonds between fibers and mechanical properties analogous to many in vivo soft tissues.
机译：与溶液相反，从溶液中静电纺丝是一种有吸引力的组织工程支架制造工艺，因为它可以形成小直径的纤维，同时消除潜在的细胞毒性溶剂。尽管如此，关于通过熔融静电纺丝形成支架的文献很少。这可能是由于与需要良好控制的高温设置有关的技术挑战以及开发合适的聚合物的困难。在本文中，专门描述了用于熔融静电纺丝的可生物降解且热稳定的聚氨酯（PU）。评价了基于（CH（2））（4）含量的二异氰酸酯，聚己内酯（PCL），1,4-丁二胺和1,4-丁二醇（BD）的脂肪族PU的聚合物配方在熔融电纺丝工艺中的实用性。最终的聚合物配方是一种催化剂纯化的PU，该催化剂基于4/1 / 3M比例的1,4-丁烷二异氰酸酯，PCL和BD，重均分子量约为40kDa，得到的无毒聚合物很容易电纺从融化。由这种聚合物进行电纺的支架包含纤维之间的点键和类似于许多体内软组织的机械性能。

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