• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Effects of alloying elements (Mn, Co, Al, W, Sn, B, C and S) on biodegradability and in vitro biocompatibility of pure iron.
【24h】

Effects of alloying elements (Mn, Co, Al, W, Sn, B, C and S) on biodegradability and in vitro biocompatibility of pure iron.

机译：合金元素（Mn，Co，Al，W，Sn，B，C和S）对纯铁的生物降解性和体外生物相容性的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pure iron was determined to be a valid candidate material for biodegradable metallic stents in recent animal tests; however, a much faster degradation rate in physiological environments was desired. C, Mn, Si, P, S, B, Cr, Ni, Pb, Mo, Al, Ti, Cu, Co, V and W are common alloying elements in industrial steels, with Cr, Ni, Mo, Cu, Ti, V and Si being acknowledged as beneficial in enhancing the corrosion resistance of iron. The purpose of the present work (using Fe-X binary alloy models) is to explore the effect of the remaining alloying elements (Mn, Co, Al, W, B, C and S) and one detrimental impurity element Sn on the biodegradability and biocompatibility of pure iron by scanning electron microscopy, X-ray diffraction, metallographic observation, tensile testing, microhardness testing, electrochemical testing, static (for 6 months) and dynamic (for 1 month with various dissolved oxygen concentrations) immersion testing, cytotoxicity testing, hemolysis and platelet adhesion testing. The results showed that the addition of all alloying elements except for Sn improved the mechanical properties of iron after rolling. Localized corrosion of Fe-X binary alloys was observed in both static and dynamic immersion tests. Except for the Fe-Mn alloy, which showed a significant decrease in corrosion rate, the other Fe-X binary alloy corrosion rates were close to that of pure iron. It was found that compared with pure iron all Fe-X binary alloys decreased the viability of the L929 cell line, none of experimental alloying elements significantly reduced the viability of vascular smooth muscle cells and all the elements except for Mn increased the viability of the ECV304 cell line. The hemolysis percentage of all Fe-X binary alloy models were less than 5%, and no sign of thrombogenicity was observed. In vitro corrosion and the biological behavior of these Fe-X binary alloys are discussed and a corresponding mechanism of corrosion of Fe-X binary alloys in Hank's solution proposed. As a concluding remark, Co, W, C and S are recommended as alloying elements for biodegradable iron-based biomaterials.
机译：在最近的动物实验中，纯铁被确定为可生物降解金属支架的有效候选材料。然而，在生理环境中需要更快的降解速度。 C，Mn，Si，P，S，B，Cr，Ni，Pb，Mo，Al，Ti，Cu，Co，V和W是工业钢中常见的合金元素，其中Cr，Ni，Mo，Cu，Ti， V和Si被认为有利于增强铁的耐腐蚀性。本研究的目的（使用Fe-X二元合金模型）是为了探索其余合金元素（Mn，Co，Al，W，B，C和S）和一种有害杂质元素Sn对生物降解性的影响。通过扫描电子显微镜，X射线衍射，金相观察，拉伸测试，显微硬度测试，电化学测试，静态（6个月）和动态（在不同溶解氧浓度下为1个月）浸入测试，细胞毒性测试，纯铁的生物相容性，溶血和血小板粘附测试。结果表明，除了锡以外，所有合金元素的添加都改善了轧制后铁的机械性能。在静态和动态浸没测试中均观察到Fe-X二元合金的局部腐蚀。除Fe-Mn合金的腐蚀速率显着降低外，其他Fe-X二元合金的腐蚀速率均接近纯铁。发现与纯铁相比，所有Fe-X二元合金均降低了L929细胞系的活力，没有实验合金元素显着降低了血管平滑肌细胞的活力，除Mn以外的所有元素均提高了ECV304的活力。细胞系。所有Fe-X二元合金模型的溶血百分比均小于5％，并且未观察到血栓形成的迹象。讨论了这些Fe-X二元合金的体外腐蚀及其生物学行为，并提出了在Hank溶液中腐蚀Fe-X二元合金的相应机理。最后，建议将Co，W，C和S作为可生物降解的铁基生物材料的合金元素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号