首页> 外文期刊>Acta biomaterialia >Assessment of using laponite cross-linked poly(ethylene oxide) for controlled cell adhesion and mineralization.
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Assessment of using laponite cross-linked poly(ethylene oxide) for controlled cell adhesion and mineralization.

机译:使用皂石交联聚环氧乙烷控制细胞粘附和矿化的评估。

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摘要

The in vitro cytocompatibility of silicate (Laponite clay) cross-linked poly(ethylene oxide) (PEO) nanocomposite films using MC3T3-E1 mouse preosteoblast cells was investigated while cell adhesion, spreading, proliferation and mineralization were assessed as a function of film composition. By combining the advantageous characteristics of PEO polymer (hydrophilic, prevents protein and cell adhesion) with those of a synthetic and layered silicate (charged, degradable and potentially bioactive) some of the physical and chemical properties of the resulting polymer nanocomposites could be controlled. Hydration, dissolution and mechanical properties were examined and related to cell adhesion. Overall, this feasibility study demonstrates the ability of using model Laponite cross-linked PEO nanocomposites to create bioactive scaffolds.
机译:研究了使用MC3T3-E1小鼠前成骨细胞的硅酸盐(Laponite粘土)交联的聚环氧乙烷(PEO)纳米复合膜的体外细胞相容性,同时评估了细胞粘附,扩散,增殖和矿化与膜组成的关系。通过将PEO聚合物的优势特性(亲水性,防止蛋白质和细胞粘附)与合成和层状硅酸盐(带电,可降解和潜在的生物活性)相结合,可以控制所得聚合物纳米复合材料的一些物理和化学性质。检查了水合,溶解和机械性能,并与细胞粘附有关。总体而言,该可行性研究证明了使用Laponite模型交联的PEO纳米复合材料制造生物活性支架的能力。

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