• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Preparation of 3-D scaffolds in the SiO2-P2O5 system with tailored hierarchical meso-macroporosity.
【24h】

Preparation of 3-D scaffolds in the SiO2-P2O5 system with tailored hierarchical meso-macroporosity.

机译：在SiO2-P2O5系统中制备具有定制的层级中观宏观性的3-D支架。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Herein we report for the first time the synthesis of three-dimensional scaffolds in the binary system SiO2-P2O5 exhibiting different scales of porosity: (i) highly ordered mesopores with diameters of ca. 4 nm; (ii) macropores with diameters in the 30-80 mum range with interconnections of ca. 2-4 and 8-9 mum; and (iii) ultra-large macropores of ca. 400 mum. The hierarchical porosity of the resulting scaffolds makes them suitable for bone tissue engineering applications. The chemical nature and mesoporosity of these matrices would allow these scaffolds to act as local controlled delivery systems of biologically active molecules, such as certain drugs to treat bone pathologies. The synthetic method consists of the combination of a single-step sol-gel route in the presence of a surfactant as the mesostructure directing agent and a biomacromolecular polymer such as methylcellulose as the macrostructure template followed by rapid prototyping technique. An exhaustive study of the aging process as well as of the rheological properties of the slurry after methylcellulose addition has been carried out to obtain hierarchical meso-macroporosity. This study allows the establishment of the time period in which the slurry presents appropriate viscosity to be extruded during the rapid prototyping once the ink is prepared. The setting up of this manufacture process at the laboratory level is important from the industrial point of view when the large-scale production of scaffolds for bone tissue repair and regeneration is targeted.
机译：在这里，我们首次报道了在二元体系SiO2-P2O5中三维支架的合成，这些支架表现出不同的孔隙率：（i）直径约200的高度有序的中孔。 4纳米; （ii）直径在30-80微米范围内的大孔，相互连接的长度大约为1。 2-4和8-9妈妈; （iii）约超大孔。 400妈所得支架的多孔性使其适合骨组织工程应用。这些基质的化学性质和介孔性将使这些支架能够充当生物活性分子（例如某些可治疗骨病的药物）的局部控制递送系统。合成方法包括在表面活性剂作为介观结构导向剂和生物大分子聚合物（如甲基纤维素）作为宏观结构模板的情况下，通过一步溶胶-凝胶路线的组合，然后进行快速原型技术。已对添加甲基纤维素后的浆料的老化过程以及流变特性进行了详尽的研究，以获得分层的中微巨观性。这项研究可以确定在油墨制备完成后，在快速成型过程中浆液呈现适当粘度的时间。从工业的角度出发，在大规模生产用于骨组织修复和再生的支架的过程中，在实验室水平上建立此制造过程非常重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号