首页> 外文期刊>Acta biomaterialia >Micropatterned TiO nanotube surfaces for site-selective nucleation of hydroxyapatite from simulated body fluid.
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Micropatterned TiO nanotube surfaces for site-selective nucleation of hydroxyapatite from simulated body fluid.

机译:微图案化的TiO纳米管表面,用于模拟体液中羟基磷灰石的位置选择性成核。

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TiO nanotube layers can provide greatly enhanced kinetics for hydroxyapatite formation from simulated body fluid compared with smooth, compact TiO surfaces. In the present work we show how this contrast in reactivity can be used to create highly defined lateral microstructures where bone-like hydroxyapatite can be deposited with very high selectivity. For this we used a photolithographic approach to produce micropatterned TiO nanotube layers surrounded by compact oxide that were then immersed in a simulated body fluid (SBF) solution. Not only the tubular vs. flat geometry but also the finding that compact oxides created in phosphate electrolytes in particular suppress apatite deposition are crucial for a very high reactivity contrast. Overall the results show the feasibility of stimulating hydroxyapatite deposition at surface locations where needed or desired. This provides a valuable tool for biomedical device design.
机译:与光滑,致密的TiO表面相比,TiO纳米管层可以大大提高从模拟体液形成羟基磷灰石的动力学。在目前的工作中,我们展示了如何利用这种反应性的对比来创建高度明确的侧向微观结构,在其中可以以非常高的选择性沉积骨状羟基磷灰石。为此,我们使用了光刻方法来生产被致密氧化物包围的微图案化TiO纳米管层,然后将其浸入模拟体液(SBF)溶液中。不仅管形几何形状对平坦几何形状,而且磷酸盐电解质中产生的致密氧化物特别抑制磷灰石沉积的发现对于非常高的反应性对比至关重要。总体而言,结果表明在需要或期望的情况下在表面位置刺激羟基磷灰石沉积的可行性。这为生物医学设备设计提供了有价值的工具。

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