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首页> 外文期刊>Acta biomaterialia >Soft tissue response to titanium dioxide nanotube modified implants.
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Soft tissue response to titanium dioxide nanotube modified implants.

机译：软组织对二氧化钛纳米管改性植入物的反应。

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Titanium is widely used clinically, yet little is known regarding the effects of modifying its three-dimensional surface geometry at the nanoscale level. In this project we have explored the in vivo response in terms of nitric oxide scavenging and fibrotic capsule formation to nano-modified titanium implant surfaces. We compared titanium dioxide (TiO(2)) nanotubes with 100 nm diameters fabricated by electrochemical anodization with TiO(2) control surfaces. Significantly lower nitric oxide was observed for the nanostructured surface in solution, suggesting that nanotubes break down nitric oxide. To evaluate the soft tissue response in vivo TiO(2) nanotube and TiO(2) control implants were placed in the rat abdominal wall for 1 and 6 weeks. A reduced fibrotic capsule thickness was observed for the nanotube surfaces for both time points. Significantly lower nitric oxide activity, measured as the presence of nitrotyrosine (P<0.05), was observed on the nanotube surface after 1 week, indicating that the reactive nitrogen species interaction is of importance. The differences observed between the titanium surfaces may be due to the catalytic properties of TiO(2), which are increased by the nanotube structure. These findings may be significant for the interaction between titanium implants in soft tissue as well as bone tissue and provide a mechanism by which to improve future clinical implants.
机译：钛在临床上被广泛使用，但对于在纳米级修饰其三维表面几何形状的影响知之甚少。在这个项目中，我们探索了体内清除一氧化氮和纤维化囊膜对纳米改性钛植入物表面的体内反应。我们比较了通过用TiO（2）控制表面进行电化学阳极氧化制造的直径为100 nm的二氧化钛（TiO（2））纳米管。在溶液中的纳米结构表面观察到明显较低的一氧化氮，表明纳米管分解了​​一氧化氮。为了评估体内的软组织反应，将TiO（2）纳米管和TiO（2）对照植入物在大鼠腹壁放置1和6周。在两个时间点，纳米管表面均观察到纤维化囊厚度降低。 1周后在纳米管表面观察到一氧化氮活性显着降低（以硝基酪氨酸的存在为衡量标准（P <0.05）），表明反应性氮物种的相互作用至关重要。在钛表面之间观察到的差异可能是由于TiO（2）的催化性能，而该性能因纳米管结构而增加。这些发现对于在软组织以及骨骼组织中的钛植入物之间的相互作用可能是重要的，并提供了改善未来临床植入物的机制。

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