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首页> 外文期刊>Acta biomaterialia >Phosphonium-based ionic liquids as modifiers for biomedical grade poly(vinyl chloride)
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Phosphonium-based ionic liquids as modifiers for biomedical grade poly(vinyl chloride)

机译：bio基离子液体作为生物医学级聚氯乙烯的改性剂

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摘要

This work reports and discusses the influence of four phosphonium-based ionic liquids (PhILs), namely trihexyl(tetradecyl) phosphonium dicyanamide, [P 6,6,6,14][dca]; trihexyl(tetradecyl) phosphonium bis(trifluoromethylsulfonyl)imide, [P 6,6,6,14][Tf 2N]; tetrabutyl phosphonium bromide, [P 4,4,4,4][Br]; and tetrabutyl phosphonium chloride, [P 4,4,4,4][Cl], on some of the chemical, physical and biological properties of a biomedical-grade suspension of poly(vinyl chloride) (PVC). The main goal of this work was to evaluate the capacity of these PhILs to modify some of the properties of neat PVC, in particular those that may allow their use as potential alternatives to traditional phthalate-based plasticizers in PVC biomedical applications. PVC films having different PhIL compositions (0, 5, 10 and 20 wt.%) were prepared (by solvent film casting) and characterised by Fourier transform infrared, thermogravimetric analysis, differential scanning calorimetry, dynamical mechanical thermal analysis, scanning electron microscopy/energy-dispersive X-ray/electron probe microanalysis, X-ray diffraction, transmittance, permeability towards oxygen and carbon dioxide, thermal degradation, contact angle measurement, water and vapour uptake, leachability and biocompatibility (haemolytic potential, thrombogenicity and cytotoxicity). A conventional organic plasticizer (di-isononyl phthalate) was used for comparison purposes. The results obtained showed that it was possible to change the neat PVC hydrophobicity, and consequently its water uptake capacity and plasticizer leachability, just by changing the PhIL employed and its composition. It was also possible to significantly change the thermal and mechanical properties of PVC films by choosing appropriate PhIL cation/anion combinations. However, a specific PhIL may not always be capable of simultaneously keeping and/or improving both physical properties. In addition, ionic halide salts were found to promote PVC dehydrochlorination. Finally, none of the prepared materials presented toxicity against Caco-2 cells, though pure [P 6,6,6,14][dca] decreased HepG2 cells viability. Moreover, PVC films with [P 6,6,6,14][dca] and [P 4,4,4,4][Cl] were found to be haemolytic and thus these PhILs must be avoided as PVC modifiers if biomedical applications are envisaged. In conclusion, from all the PhILs tested, [P 6,6,6,14][Tf 2N] showed the most promising results regarding blood compatibility, leaching and permeability to gases of PVC films. The results presented are a strong indicator that adequate PhILs may be successfully employed as PVC multi-functional plasticizers for a wide range of potential applications, including those in the biomedical field.
机译：这项工作报告并讨论了四种phospho基离子液体（PhIL）的影响，即三己基（十四烷基）phospho双氰胺[P 6,6,6,14] [dca];三（十六烷基）phospho双（三氟甲基磺酰基）酰亚胺，[P 6,6,6,14] [Tf 2N];四丁基溴化phospho，[P 4,4,4,4] [Br];氯化四丁基phospho氯化物[P 4,4,4,4] [Cl]，有关生物医学级聚氯乙烯（PVC）悬浮液的一些化学，物理和生物学特性。这项工作的主要目的是评估这些PhIL改性纯PVC某些性能的能力，尤其是那些可以将其用作PVC生物医学应用中传统邻苯二甲酸酯类增塑剂的潜在替代品的能力。 （通过溶剂膜流延）制备具有不同PhIL组成（0、5、10和20重量％）的PVC膜，并通过傅里叶变换红外，热重分析，差示扫描量热法，动态机械热分析，扫描电子显微镜/能量表征。 -分散X射线/电子探针显微分析，X射线衍射，透射率，对氧气和二氧化碳的渗透性，热降解，接触角测量，水和蒸气吸收，可浸出性和生物相容性（溶血潜力，血栓形成性和细胞毒性）。为了比较的目的，使用了常规的有机增塑剂（邻苯二甲酸二异壬酯）。所得结果表明，仅通过改变所用的PhIL及其组成，就可以改变纯净的PVC疏水性，从而改变其吸水能力和增塑剂浸出能力。通过选择合适的PhIL阳离子/阴离子组合，也可以显着改变PVC膜的热和机械性能。但是，特定的PhIL可能并不总是能够同时保持和/或改善两种物理特性。另外，发现离子卤化物盐促进PVC脱氯化氢。最后，尽管纯的[P 6,6,6,14] [dca]降低了HepG2细胞的活力，但没有一种制备的材料对Caco-2细胞具有毒性。此外，发现具有[P 6,6,6,14] [dca]和[P 4,4,4,4] [Cl]的PVC膜具有溶血性，因此如果在生物医学应用中应避免使用这些PhIL作为PVC改性剂被设想。总之，在所有测试的PhIL中，[P 6,6,6,14] [Tf 2N]在血液相容性，浸出和PVC膜的气体渗透性方面显示出最有希望的结果。给出的结果有力地表明，足够的PhIL可以成功地用作PVC多功能增塑剂，用于包括生物医学领域在内的广泛潜在应用。

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