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首页> 外文期刊>Acta biomaterialia >Fabrication, mechanical and in vivo performance of polycaprolactone/ tricalcium phosphate composite scaffolds
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Fabrication, mechanical and in vivo performance of polycaprolactone/ tricalcium phosphate composite scaffolds

机译：聚己内酯/磷酸三钙复合支架的制备，力学性能和体内性能

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摘要

This paper explores the use of selective laser sintering (SLS) for the generation of bone tissue engineering scaffolds from polycaprolactone (PCL) and PCL/tricalcium phosphate (TCP). Different scaffold designs are generated, and assessed from the point of view of manufacturability, porosity and mechanical performance. Large scaffold specimens are produced, with a preferred design, and are assessed through an in vivo study of the critical size bone defect in sheep tibia with subsequent microscopic, histological and mechanical evaluation. Further explorations are performed to generate scaffolds with increasing TCP content. Scaffold fabrication from PCL and PCL/TCP mixtures with up to 50 mass% TCP is shown to be possible. With increasing macroporosity the stiffness of the scaffolds is seen to drop; however, the stiffness can be increased by minor geometrical changes, such as the addition of a cage around the scaffold. In the animal study the selected scaffold for implantation did not perform as well as the TCP control in terms of new bone formation and the resulting mechanical performance of the defect area. A possible cause for this is presented.
机译：本文探讨了选择性激光烧结（SLS）从聚己内酯（PCL）和PCL /磷酸三钙（TCP）生成骨组织工程支架中的用途。产生了不同的支架设计，并从可制造性，孔隙率和机械性能的角度对其进行了评估。生产具有最佳设计的大型支架标本，并通过对绵羊胫骨的临界尺寸骨缺损的体内研究进行评估，然后进行显微镜，组织学和力学评估。进行进一步的研究以产生具有增加的TCP含量的支架。由PCL和PCL / TCP混合物（TCP含量最高为50质量％）制成的脚手架被证明是可行的。随着大孔隙率的增加，脚手架的刚度下降。但是，刚度可以通过较小的几何变化来增加，例如在支架周围增加一个笼子。在动物研究中，就新的骨形成和由此产生的缺损区域的机械性能而言，所选择的用于植入的支架表现不如TCP控制。提出了可能的原因。

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