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首页> 外文期刊>Acta biomaterialia >Current views on calcium phosphate osteogenicity and the translation into effective bone regeneration strategies.
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Current views on calcium phosphate osteogenicity and the translation into effective bone regeneration strategies.

机译：当前对磷酸钙成骨性的看法以及对有效骨再生策略的转化。

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Calcium phosphate (CaP) has traditionally been used for the repair of bone defects because of its strong resemblance to the inorganic phase of bone matrix. Nowadays, a variety of natural or synthetic CaP-based biomaterials are produced and have been extensively used for dental and orthopaedic applications. This is justified by their biocompatibility, osteoconductivity and osteoinductivity (i.e. the intrinsic material property that initiates de novo bone formation), which are attributed to the chemical composition, surface topography, macro/microporosity and the dissolution kinetics. However, the exact molecular mechanism of action is unknown. This review paper first summarizes the most important aspects of bone biology in relation to CaP and the mechanisms of bone matrix mineralization. This is followed by the research findings on the effects of calcium (Ca2?) and phosphate (PO?3?) ions on the migration, proliferation and differentiation of osteoblasts during in vivo bone formation and in vitro culture conditions. Further, the rationale of using CaP for bone regeneration is explained, focusing thereby specifically on the material's osteoinductive properties. Examples of different material forms and production techniques are given, with the emphasis on the state-of-the art in fine-tuning the physicochemical properties of CaP-based biomaterials for improved bone induction and the use of CaP as a delivery system for bone morphogenetic proteins. The use of computational models to simulate the CaP-driven osteogenesis is introduced as part of a bone tissue engineering strategy in order to facilitate the understanding of cell-material interactions and to gain further insight into the design and optimization of CaP-based bone reparative units. Finally, limitations and possible solutions related to current experimental and computational techniques are discussed.
机译：由于磷酸钙（CaP）与骨骼基质的无机相非常相似，因此传统上已将其用于骨骼缺损的修复。如今，生产了多种天然或合成的基于CaP的生物材料，并已广泛用于牙科和整形外科领域。其生物相容性，骨电导率和骨电导率（即引发从头形成骨的内在材料特性）证明了这一点，这归因于化学成分，表面形貌，宏观/微孔率和溶解动力学。但是，确切的分子作用机理尚不清楚。这篇综述文章首先总结了与CaP和骨基质矿化机制有关的骨生物学最重要的方面。其次是钙离子（Ca 2+）和磷酸根（PO 3 3）对体内成骨和体外培养条件下成骨细胞迁移，增殖和分化的影响的研究发现。此外，解释了使用CaP进行骨骼再生的原理，从而重点关注了该材料的骨诱导特性。给出了不同材料形式和生产技术的示例，重点是对基于CaP的生物材料的理化特性进行微调以改善骨骼诱导的最新技术，以及将CaP用作骨形态发生学的传递系统蛋白质。作为骨组织工程策略的一部分，引入了使用计算模型来模拟CaP驱动的成骨作用，以促进对细胞-材料相互作用的理解，并进一步了解基于CaP的骨修复单元的设计和优化。 。最后，讨论了与当前实验和计算技术有关的局限性和可能的​​解决方案。

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