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首页> 外文期刊>Acta biomaterialia >Preparation, mechanical property and cytocompatibility of poly(L-lactic acid)/calcium silicate nanocomposites with controllable distribution of calcium silicate nanowires.
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Preparation, mechanical property and cytocompatibility of poly(L-lactic acid)/calcium silicate nanocomposites with controllable distribution of calcium silicate nanowires.

机译：具有可控制的硅酸钙纳米线分布的聚（L-乳酸）/硅酸钙纳米复合材料的制备，力学性能和细胞相容性。

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摘要

How to accurately control the microstructure of bioactive inorganic/organic nanocomposites still remains a significant challenge, which is of great importance in influencing their mechanical strength and biological properties. In this study, using a combined method of electrospinning and hot press processing, calcium silicate hydrate (CSH) nanowire/poly(L-lactide) (PLLA) nanocomposites with controllable microstructures and tailored mechanical properties were successfully prepared as potential bone graft substitutes. The electrospun hybrid nanofibers with various degrees of alignment were stacked together in a predetermined manner and hot pressed into hierarchically structured nanocomposites. The relationship between the microstructure and mechanical properties of the as-prepared nanocomposites were systematically evaluated. The results showed that CSH nanowires in a PLLA matrix were able to be controlled from completely randomly oriented to uniaxially aligned, and then hierarchically organized with different interlayer angles, leading to corresponding nanocomposites with improved mechanical properties and varied anisotropies. It was also found that the bending strength of nanocomposites with 5 wt.% CSH nanowires (130 MPa) was significantly higher than that of pure PLLA (86 MPa) and other composites. The addition of CSH nanowires greatly enhanced the hydrophilicity and apatite-forming ability of PLLA films, as well as the attachment and proliferation of bone marrow stromal cells. The study suggested that a combination of electrospinning and hot pressing is a viable means to control the microstructure and mechanical properties, and improve the mineralization ability and cellular responses, of CSH/PLLA nanocomposites for potential bone repair applications.
机译：如何精确地控制生物活性无机/有机纳米复合材料的微观结构仍然是一个重大挑战，这对影响其机械强度和生物学特性具有重要意义。在这项研究中，采用电纺和热压加工相结合的方法，成功制备了具有可控的微结构和定制机械性能的水合硅酸钙（CSH）纳米线/聚（L-丙交酯）（PLLA）纳米复合材料，作为潜在的骨移植替代物。将具有不同取向度的电纺杂化纳米纤维以预定方式堆叠在一起，并热压成分层结构的纳米复合材料。系统评价了制备的纳米复合材料的微观结构与力学性能之间的关系。结果表明，PLLA基质中的CSH纳米线能够从完全随机取向控制为单轴排列，然后以不同的夹层角度进行分层组织，从而得到具有改善的机械性能和不同各向异性的相应纳米复合材料。还发现具有5重量％的CSH纳米线的纳米复合材料（130MPa）的弯曲强度显着高于纯PLLA（86MPa）和其他复合材料的抗弯强度。 CSH纳米线的添加极大地增强了PLLA膜的亲水性和形成磷灰石的能力，以及骨髓基质细胞的附着和增殖。研究表明，静电纺丝和热压相结合是控制CSH / PLLA纳米复合材料的微观结构和力学性能，提高其矿化能力和细胞反应的可行方法，可用于潜在的骨修复应用。

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