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首页> 外文期刊>Acta biomaterialia >Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite
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Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite

机译：生物活性铁掺杂羟基磷灰石的本征磁性和高温

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摘要

The use of magnetic activation has been proposed to answer the growing need for assisted bone and vascular remodeling during template/scaffold regeneration. With this in mind, a synthesis procedure was developed to prepare bioactive (Fe 2+/Fe 3+)-doped hydroxyapatite (Fe-HA), endowed with superparamagnetic-like properties. This new class of magnetic hydroxyapatites can be potentially employed to develop new magnetic ceramic scaffolds with enhanced regenerative properties for bone surgery; in addition, magnetic Fe-HA can find application in anticancer therapies, to replace the widely used magnetic iron oxide nanoparticles, whose long-term cytotoxicity was recently found to reach harmful levels. An extensive physicochemical, microstructural and magnetic characterization was performed on the obtained Fe-HA powders, and demonstrated that the simultaneous addition of Fe 2+ and Fe 3+ ions during apatite nucleation under controlled synthesis conditions induces intrinsic magnetization in the final product, minimizing the formation of magnetite as secondary phase. This result potentially opens new perspectives for biodevices aimed at bone regeneration and for anti-cancer therapies based on hyperthermia.
机译：已经提出使用磁活化来解决在模板/支架再生期间对辅助的骨骼和血管重塑的日益增长的需求。考虑到这一点，开发了一种合成程序来制备具有超顺磁性的特性的生物活性（Fe 2 + / Fe 3+）掺杂的羟基磷灰石（Fe-HA）。这种新型的磁性羟基磷灰石可潜在地用于开发具有增强的再生特性的新型磁性陶瓷支架，用于骨外科手术。此外，磁性Fe-HA可以在抗癌治疗中找到应用，以取代广泛使用的磁性氧化铁纳米颗粒，该磁性纳米颗粒的长期细胞毒性最近被发现达到有害水平。对获得的Fe-HA粉末进行了广泛的物理化学，微观结构和磁学表征，证明了在受控合成条件下磷灰石成核过程中同时添加Fe 2+和Fe 3+离子会诱导最终产品的固有磁化强度，从而最大程度地降低了形成磁铁矿作为第二相。该结果潜在地为针对骨再生的生物装置以及基于热疗的抗癌疗法开辟了新的前景。

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