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首页> 外文期刊>Acta biomaterialia >Static and dynamic nanomechanical properties of human skin tissue using atomic force microscopy: effect of scarring in the upper dermis.
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Static and dynamic nanomechanical properties of human skin tissue using atomic force microscopy: effect of scarring in the upper dermis.

机译：使用原子力显微镜对人体皮肤组织的静态和动态纳米力学性能：上皮瘢痕形成的影响。

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摘要

Following traumatic injury, skin has the capacity to repair itself through a complex cascade of biochemical change. The dermis, which contains a load-bearing collagenous network structure, is remodelled over a long period of time, affecting its mechanical behaviour. This study examines the nanomechanical and viscoelastic properties of the upper dermis from human skin that includes both healthy intact and scarred tissue. Extensive nanoindentation analysis shows that the dermal scar tissue exhibits stiffer behaviour than the healthy intact skin. The scar skin also shows weaker viscoelastic creep and capability to dissipate energy at physiologically relevant frequencies than the adjacent intact skin. These results are discussed in conjunction with a visual change in the orientation of collagenous fibrils in the scarred dermis compared with normal dermis, as shown by atomic force microscopy imaging.
机译：遭受创伤后，皮肤具有通过复杂的生化变化级联进行自我修复的能力。含有承载性胶原网络结构的真皮经过长时间的重塑，影响其机械性能。这项研究检查了人类皮肤上层真皮的纳米力学和粘弹性特性，其中包括健康的完整组织和瘢痕组织。广泛的纳米压痕分析表明，与健康完整的皮肤相比，真皮疤痕组织表现出更硬的行为。与相邻的完整皮肤相比，疤痕皮肤还显示出较弱的粘弹性蠕变和以生理相关频率消散能量的能力。如原子力显微镜成像所显示的，这些结果与疤痕真皮中胶原纤维的取向与正常真皮相比的视觉变化相结合进行了讨论。

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