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Discovery of low mucus adhesion surfaces

机译：发现低黏液黏附表面

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Mucus secretion from the body is ubiquitous, and finding materials that resist mucus adhesion is a major technological challenge. Here, using a high throughput platform with photo-induced graft polymerization, we first rapidly synthesized, screened and tested a library of 55 different surfaces from six functional monomer classes to discover porcine intestinal low mucus adhesion surfaces using a 1 h static mucus adsorption protocol. From this preliminary screen, two chemistries, a zwitterionic ([2-(acryloyloxy)ethyl] trimethylammonium chloride) and a multiple hydroxyl (N-[tris(hydroxymethyl) methyl]acrylamide) surface, exhibited significantly low mucus adhesion from a Langmuir-type isotherm when exposed to increasing concentrations of mucus for 24 h. Apolar or hydrophobic interactions were likely the dominant attractive forces during mucus binding since many polar or hydrophilic monomers reduced mucus adhesion. Hansen solubility parameters were used to illustrate the importance of monomer polarity and hydrogen bonding in reducing mucus adsorption. For a series of polyethylene glycol (PEG) monomers with changing molecular weight from 144 g mol-1 to 1100 g mol-1, we observed an excellent linear correlation (R2 = 0.998) between relative amount adsorbed and the distance from a water point in a specialized Hansen solubility parameter plot, emphasizing the role of surface-water interactions for PEG modified surfaces. ? 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
机译：人体粘液的分泌是普遍存在的，寻找能够抵抗粘液粘附的材料是一项重大的技术挑战。在这里，我们使用具有光诱导接枝聚合反应的高通量平台，首先快速合成，筛选并测试了来自六个功能单体类别的55个不同表面的库，以使用1 h静态粘液吸附方案发现猪肠道低粘液粘附表面。从该初步筛选中，两种化学物质，两性离子（[2-（丙烯酰氧基）乙基]三甲基氯化铵）和多羟基（N- [三（羟甲基）甲基]丙烯酰胺）表面表现出明显低的郎格缪尔黏液粘附性。当暴露于浓度不断增加的粘液中24小时后，等温线上升。非极性或疏水性相互作用可能是粘液结合过程中的主要吸引力，因为许多极性或亲水性单体均会降低粘液的附着力。使用汉森溶解度参数来说明单体极性和氢键在减少粘液吸附中的重要性。对于一系列分子量从144 g mol-1变为1100 g mol-1的聚乙二醇（PEG）单体，我们观察到相对吸附量与距水点的距离之间存在极好的线性相关性（R2 = 0.998）。专门的Hansen溶解度参数图，强调了PEG修饰表面的地表水相互作用。 ？ 2012年Acta Materialia Inc.由Elsevier Ltd.发行。保留所有权利。

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