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首页> 外文期刊>Acta biomaterialia >Multiaxial mechanical response and constitutive modeling of esophageal tissues: Impact on esophageal tissue engineering
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Multiaxial mechanical response and constitutive modeling of esophageal tissues: Impact on esophageal tissue engineering

机译：食管组织的多轴力学响应和本构模型：对食管组织工程的影响

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摘要

Congenital defects of the esophagus are relatively frequent, with 1 out of 2500 babies suffering from such a defect. A new method of treatment by implanting tissue engineered esophagi into newborns is currently being developed and tested using ovine esophagi. For the reconstruction of the biological function of native tissues with engineered esophagi, their cellular structure as well as their mechanical properties must be considered. Since very limited mechanical and structural data for the esophagus are available, the aim of this study was to investigate the multiaxial mechanical behavior of the ovine esophagus and the underlying microstructure. Therefore, uniaxial tensile, biaxial tensile and extension-inflation tests on esophagi were performed. The underlying microstructure was examined in stained histological sections through standard optical microscopy techniques. Moreover, the uniaxial ultimate tensile strength and residual deformations of the tissue were determined. Both the mucosa-submucosa and the muscle layers showed nonlinear and anisotropic mechanical behavior during uniaxial, biaxial and inflation testing. Cyclical inflation of the intact esophageal tube caused marked softening of the passive esophagi in the circumferential direction. The rupture strength of the mucosa-submucosa layer was much higher than that of the muscle layer. Overall, the ovine esophagus showed a heterogeneous and anisotropic behavior with different mechanical properties for the individual layers. The intact and layer-specific multiaxial properties were characterized using a well-known three-dimensional microstructurally based strain-energy function. This novel and complete set of data serves the basis for a better understanding of tissue remodeling in diseased esophagi and can be used to perform computer simulations of surgical interventions or medical-device applications.
机译：食道的先天性缺陷相对频繁，每2500名婴儿中就有1名患有这种缺陷。目前正在开发一种通过将组织工程化食管植入新生儿的新治疗方法，并使用绵羊食管进行了测试。为了用工程食道重建天然组织的生物学功能，必须考虑其细胞结构以及机械性能。由于食道的机械和结构数据非常有限，因此本研究的目的是研究绵羊食道的多轴力学行为及其潜在的微观结构。因此，对食管进行了单轴拉伸，双轴拉伸和膨胀膨胀试验。通过标准的光学显微镜技术在染色的组织学切片中检查了潜在的微观结构。此外，确定了组织的单轴极限抗拉强度和残余变形。在单轴，双轴和膨胀测试过程中，粘膜下粘膜下层和肌肉层均显示出非线性和各向异性的力学行为。完整食管的周期性膨胀导致被动食管在圆周方向上明显软化。粘膜-粘膜下层的断裂强度比肌肉层的断裂强度高得多。总体而言，绵羊食道表现出异质性和各向异性行为，各层的机械特性不同。使用众所周知的基于三维微结构的应变能函数来表征完整的和特定于层的多轴特性。这一新颖而完整的数据集为更好地了解患病食管中的组织重塑提供了基础，并可用于执行外科手术或医疗器械应用的计算机模拟。

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