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首页> 外文期刊>Acta biomaterialia >Development of injectable organic/inorganic colloidal composite gels made of self-assembling gelatin nanospheres and calcium phosphate nanocrystals
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Development of injectable organic/inorganic colloidal composite gels made of self-assembling gelatin nanospheres and calcium phosphate nanocrystals

机译：由自组装明胶纳米球和磷酸钙纳米晶体制成的可注射有机/无机胶体复合凝胶的开发

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Colloidal gels are a particularly attractive class of hydrogels for applications in regenerative medicine, and allow for a "bottom-up" fabrication of multi-functional biomaterials by employing micro- or nanoscale particles as building blocks to assemble into shape-specific bulk scaffolds. So far, however, the synthesis of colloidal composite gels composed of both organic and inorganic particles has hardly been investigated. The current study has focused on the development of injectable colloidal organic-inorganic composite gels using calcium phosphate (CaP) nanoparticles and gelatin (Gel) nanospheres as building blocks. These novel Gel-CaP colloidal composite gels exhibited a strongly enhanced gel elasticity, shear-thinning and self-healing behavior, and gel stability at high ionic strengths, while chemical - potentially cytotoxic - functionalizations were not necessary to introduce sufficiently strong cohesive interactions. Moreover, it was shown in vitro that osteoconductive CaP nanoparticles can be used as an additional tool to reduce the degradation rate of otherwise fast-degradable gelatin nanospheres and fine-tune the control over the release of growth factors. Finally, it was shown that these colloidal composite gels support attachment, spreading and proliferation of cultured stem cells. Based on these results, it can be concluded that proof-of-principle has been obtained for the design of novel advanced composite materials made of nanoscale particulate building blocks which exhibit great potential for use in regenerative medicine.
机译：胶体凝胶是一类特别有吸引力的水凝胶，用于再生医学，并通过使用微米或纳米级的颗粒作为构建块组装成特定形状的整体支架，从而实现了多功能生物材料的“自下而上”制造。然而，到目前为止，几乎没有研究由有机和无机颗粒组成的胶体复合凝胶的合成。当前的研究集中在开发使用磷酸钙（CaP）纳米颗粒和明胶（Gel）纳米球作为构建基的可注射胶体有机-无机复合凝胶。这些新颖的Gel-CaP胶体复合凝胶在高离子强度下表现出显着增强的凝胶弹性，剪切稀化和自修复行为，以及凝胶稳定性，而引入足够强的内聚相互作用则不需要化学-潜在的细胞毒性-功能化。此外，体外研究表明，骨传导性CaP纳米颗粒可以用作另外的工具，以降低原本可以快速降解的明胶纳米球的降解速率，并微调对生长因子释放的控制。最后，表明这些胶体复合凝胶支持培养的干细胞的附着，扩散和增殖。基于这些结果，可以得出结论，已经获得了用于设计由纳米级颗粒构建体制成的新型先进复合材料的原理证明，其在再生医学中具有巨大的潜力。

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