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Prevention of peritoneal adhesions using polymeric rheological blends

机译:使用聚合物流变混合物预防腹膜粘连

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摘要

The effectiveness of rheological blends of high molecular weight hyaluronic acid (HA) and low molecular weight hydroxypropyl methylcellulose (HPMC) in the prevention of peritoneal adhesions post-surgery is demonstrated. The physical mixture of the two carbohydrates increased the dwell time in the peritoneum while significantly improving the injectability of the polymer compared with HA alone. HA-HPMC treatment decreased the total adhesion area by ~70% relative to a saline control or no treatment in a repeated cecal injury model in the rabbit. No significant cytotoxicity and minimal inflammation were associated with the blend. Furthermore, no chemical or physical processing was required prior to their use beyond simple mixing.
机译:证明了高分子量透明质酸(HA)和低分子量羟丙基甲基纤维素(HPMC)的流变混合物在预防术后腹膜粘连方面的有效性。与单独的HA相比,两种碳水化合物的物理混合物增加了在腹膜中的停留时间,同时显着提高了聚合物的可注射性。在反复的盲肠损伤模型中,HA-HPMC处理相对于盐水对照组或不进行处理的总粘着面积减少了约70%。该混合物没有明显的细胞毒性和最小的炎症。此外,除了简单的混合之外,在使用之前不需要化学或物理处理。

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